Molecules 2014, 19(4), 3869-3882; doi:10.3390/molecules19043869
Article

Interaction Between Different Extracts of Hypericum perforatum L. from Serbia and Pentobarbital, Diazepam and Paracetamol

1email, 2email, 1,* email, 2email, 1email, 3email and 1email
Received: 20 December 2013; in revised form: 16 March 2014 / Accepted: 19 March 2014 / Published: 28 March 2014
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs. This study examined the influence of acute pretreatment with different extracts of Hypericum perforatum from Serbia on pentobarbital-induced sleeping time, impairment of motor coordination caused by diazepam and paracetamol pharmacokinetics in mice. Ethanolic extract, aqueous extract, infusion, tablet and capsule of Hypericum perforatum were used in this experiment. The profile of Hypericum perforatum extracts as well as paracetamol plasma concentration was determined using RP-HPLC analysis. By quantitative HPLC analysis of active principles, it has been proven that Hypericum perforatum ethanolic extract has the largest content of naphtodianthrones: hypericin (57.77 µg/mL) and pseudohypericin (155.38 µg/mL). Pretreatment with ethanolic extract of Hypericum perforatum potentiated the hypnotic effect of pentobarbital and impairment of motor coordination caused by diazepam to the greatest extent and also increased paracetamol plasma concentration in comparison to the control group. These results were in correlation with naphtodianthrone concentrations. The obtained results have shown a considerable influence of Hypericum perforatum on pentobarbital and diazepam pharmacodynamics and paracetamol pharmacokinetics.
Keywords: naphtodianthrones; hypericin; pentobarbital induced sleeping time; rotarod; paracetamol plasma concentration
PDF Full-text Download PDF Full-Text [379 KB, uploaded 18 June 2014 20:38 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Rašković, A.; Cvejić, J.; Stilinović, N.; Goločorbin-Kon, S.; Vukmirović, S.; Mimica-Dukić, N.; Mikov, M. Interaction Between Different Extracts of Hypericum perforatum L. from Serbia and Pentobarbital, Diazepam and Paracetamol. Molecules 2014, 19, 3869-3882.

AMA Style

Rašković A, Cvejić J, Stilinović N, Goločorbin-Kon S, Vukmirović S, Mimica-Dukić N, Mikov M. Interaction Between Different Extracts of Hypericum perforatum L. from Serbia and Pentobarbital, Diazepam and Paracetamol. Molecules. 2014; 19(4):3869-3882.

Chicago/Turabian Style

Rašković, Aleksandar; Cvejić, Jelena; Stilinović, Nebojša; Goločorbin-Kon, Svetlana; Vukmirović, Saša; Mimica-Dukić, Neda; Mikov, Momir. 2014. "Interaction Between Different Extracts of Hypericum perforatum L. from Serbia and Pentobarbital, Diazepam and Paracetamol." Molecules 19, no. 4: 3869-3882.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert