Molecules 2014, 19(2), 2166-2180; doi:10.3390/molecules19022166
Article

Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

1,* email, 2,3email, 1email, 1,4email, 1email, 5email, 1email and 1email
Received: 10 January 2014; in revised form: 8 February 2014 / Accepted: 10 February 2014 / Published: 18 February 2014
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
Keywords: Plasmodium falciparum; antimalarial agents; quinoxaline; quinoxaline 1,4-di-N-oxide; chalcone
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MDPI and ACS Style

Gil, A.; Pabón, A.; Galiano, S.; Burguete, A.; Pérez-Silanes, S.; Deharo, E.; Monge, A.; Aldana, I. Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents. Molecules 2014, 19, 2166-2180.

AMA Style

Gil A, Pabón A, Galiano S, Burguete A, Pérez-Silanes S, Deharo E, Monge A, Aldana I. Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents. Molecules. 2014; 19(2):2166-2180.

Chicago/Turabian Style

Gil, Ana; Pabón, Adriana; Galiano, Silvia; Burguete, Asunción; Pérez-Silanes, Silvia; Deharo, Eric; Monge, Antonio; Aldana, Ignacio. 2014. "Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents." Molecules 19, no. 2: 2166-2180.

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