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Molecules 2014, 19(2), 1622-1634; doi:10.3390/molecules19021622
Article

4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles

1
, 1
, 2
 and 1,*
Received: 23 December 2013; in revised form: 17 January 2014 / Accepted: 23 January 2014 / Published: 28 January 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract: This study describes a one-pot synthesis of superparamagnetic maghemite-based 4-aminobenzoic acid-coated spherical core-shell nanoparticles (PABA@FeNPs) as suitable nanocomposites potentially usable as magnetic carriers for drug delivery. The PABA@FeNPs system was subsequently functionalized by the activated species (1* and 2*) of highly in vitro cytotoxic cis-[PtCl2(3Claza)2] (1; 3Claza stands for 3-chloro-7-azaindole) or cis-[PtCl2(5Braza)2] (2; 5Braza stands for 5-bromo-7-azaindole), which were prepared by a silver(I) ion assisted dechlorination of the parent dichlorido complexes. The products 1*@PABA@FeNPs and 2*@PABA@FeNPs, as well as an intermediate PABA@FeNPs, were characterized by a combination of various techniques, such as Mössbauer, FTIR and EDS spectroscopy, thermal analysis, SEM and TEM. The results showed that the products consist of well-dispersed maghemite-based nanoparticles of 13 nm average size that represent an easily obtainable system for delivery of highly cytotoxic cisplatin-like complexes in oncological practice.
Keywords: maghemite; nanoparticles; magnetic; platinum complexes; 7-azaindole derivatives; drug delivery maghemite; nanoparticles; magnetic; platinum complexes; 7-azaindole derivatives; drug delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Štarha, P.; Stavárek, M.; Tuček, J.; Trávníček, Z. 4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles. Molecules 2014, 19, 1622-1634.

AMA Style

Štarha P, Stavárek M, Tuček J, Trávníček Z. 4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles. Molecules. 2014; 19(2):1622-1634.

Chicago/Turabian Style

Štarha, Pavel; Stavárek, Martin; Tuček, Jiří; Trávníček, Zdeněk. 2014. "4-Aminobenzoic Acid-Coated Maghemite Nanoparticles as Potential Anticancer Drug Magnetic Carriers: A Case Study on Highly Cytotoxic Cisplatin-Like Complexes Involving 7-Azaindoles." Molecules 19, no. 2: 1622-1634.



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