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Molecules 2014, 19(12), 20975-20987; doi:10.3390/molecules191220975

Four New Furostanol Saponins from the Rhizomes and Roots of Smilax scobinicaulis and Their Cytotoxicity

1
College of Life Science, Northwest A&F University, Yangling 712100, Shaanxi, China
2
Key Laboratory of Southern Subtropical Plant Diversity, Shenzhen Fairy Lake Botanical Garden, Chinese Academy of Sciences, 160 Xianhu Road, Liantang, Shenzhen 518004, China
3
Shenzhen Boton Flavors & Fragrances Co., Ltd., 19 Daxin Road, Nanshan, Shenzhen 518051, China
*
Author to whom correspondence should be addressed.
Received: 15 September 2014 / Revised: 21 November 2014 / Accepted: 2 December 2014 / Published: 15 December 2014
(This article belongs to the Section Natural Products)
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Abstract

Four new furostanol saponins 14, along with two known furostanol saponins 5 and 6 and one known spirostanol saponin 7 were isolated from the rhizomes and roots of Smilax scobinicaulis. The structures of the new saponins were elucidated as 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one-3-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (1), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-22-methoxyl-6-one (2), 26-O-β-D-glucopyranoside-3β,26-dihydroxy-(25R)-5α-furostan-20(22)-en-6-one (3), 26-O-β-D-glucopyranoside-3β,23,26-trihydroxy-(23R, 25R)-5α-furostan-20(22)-en-6-one (4) on the basis of spectroscopic analysis. The isolated saponins were evaluated for cytotoxic activity against two human cancer cell lines including Hela (cervical carcinoma) and SMMC-7221 (hepatocellular carcinoma). Compounds 1 and 7 demonstrated cytotoxicity against the tested cell lines. View Full-Text
Keywords: Smilax scobinicaulis; furostanol saponins; cytotoxic activity Smilax scobinicaulis; furostanol saponins; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xu, J.; Feng, S.; Wang, Q.; Cao, Y.; Sun, M.; Zhang, C. Four New Furostanol Saponins from the Rhizomes and Roots of Smilax scobinicaulis and Their Cytotoxicity. Molecules 2014, 19, 20975-20987.

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