Next Article in Journal
An Insecticidal Compound Produced by an Insect-Pathogenic Bacterium Suppresses Host Defenses through Phenoloxidase Inhibition
Previous Article in Journal
Combined Dynamic Light Scattering and Raman Spectroscopy Approach for Characterizing the Aggregation of Therapeutic Proteins
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(12), 20906-20912; doi:10.3390/molecules191220906

Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis

1
School of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China
2
The Second Hospital of Nanjing, 1-1 ZhongFu Road, Nanjing 210003, China
*
Authors to whom correspondence should be addressed.
Received: 12 November 2014 / Revised: 7 December 2014 / Accepted: 9 December 2014 / Published: 12 December 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [711 KB, uploaded 12 December 2014]   |  

Abstract

Radix isatidis (Banlangen), a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development. View Full-Text
Keywords: Radix isatidis; isoquinoline derivative; anti-viral activity Radix isatidis; isoquinoline derivative; anti-viral activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

He, L.-W.; Liu, H.-Q.; Chen, Y.-Q.; Yang, J.-Y.; Wang, T.-L.; Li, W. Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis. Molecules 2014, 19, 20906-20912.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top