Two New Coumarins from Talaromyces flavus
AbstractTwo new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher’s method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-Aβ42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ42 aggregation activity, and this is the first report on the Aβ42 inhibitory aggregation activity of coumarins. View Full-Text
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He, J.-W.; Qin, D.-P.; Gao, H.; Kuang, R.-Q.; Yu, Y.; Liu, X.-Z.; Yao, X.-S. Two New Coumarins from Talaromyces flavus. Molecules 2014, 19, 20880-20887.
He J-W, Qin D-P, Gao H, Kuang R-Q, Yu Y, Liu X-Z, Yao X-S. Two New Coumarins from Talaromyces flavus. Molecules. 2014; 19(12):20880-20887.Chicago/Turabian Style
He, Jun-Wei; Qin, Da-Peng; Gao, Hao; Kuang, Run-Qiao; Yu, Yang; Liu, Xing-Zhong; Yao, Xin-Sheng. 2014. "Two New Coumarins from Talaromyces flavus." Molecules 19, no. 12: 20880-20887.