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Molecules 2014, 19(12), 20880-20887; doi:10.3390/molecules191220880

Two New Coumarins from Talaromyces flavus

1
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China
2
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
3
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 22 October 2014 / Revised: 28 November 2014 / Accepted: 9 December 2014 / Published: 12 December 2014
(This article belongs to the Section Natural Products)
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Abstract

Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher’s method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-Aβ42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aβ42 aggregation activity, and this is the first report on the Aβ42 inhibitory aggregation activity of coumarins. View Full-Text
Keywords: Talaromyces flavus; coumarin; structure elucidation; biological activities Talaromyces flavus; coumarin; structure elucidation; biological activities
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MDPI and ACS Style

He, J.-W.; Qin, D.-P.; Gao, H.; Kuang, R.-Q.; Yu, Y.; Liu, X.-Z.; Yao, X.-S. Two New Coumarins from Talaromyces flavus. Molecules 2014, 19, 20880-20887.

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