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Molecules 2014, 19(12), 20382-20390; doi:10.3390/molecules191220382

Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
School of Nutrition, College of Health Care and Management, Chung Shan Medical University, Taichung 40201, Taiwan
Research Center for Natural Product and New Drug, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan
Research and Development Center of Chinese Herbal Medicines and New Drugs, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80708, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 27 October 2014 / Revised: 25 November 2014 / Accepted: 27 November 2014 / Published: 5 December 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [701 KB, uploaded 5 December 2014]   |  


Four new sulfur-containing compounds, named clinamides A-C (13), and 2-cis-entadamide A (4), were isolated together with three known compounds from the bioactive ethanol extract of the aerial parts of Clinacanthus nutans. These secondary metabolites possess sulfur atoms and acrylamide functionalities. The structures of the isolated components were established by interpretation of their spectroscopic data, especially 1D and 2D NMR. View Full-Text
Keywords: Clinacanthus nutans; sulfur-containing compound Clinacanthus nutans; sulfur-containing compound

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tu, S.-F.; Liu, R.H.; Cheng, Y.-B.; Hsu, Y.-M.; Du, Y.-C.; El-Shazly, M.; Wu, Y.-C.; Chang, F.-R. Chemical Constituents and Bioactivities of Clinacanthus nutans Aerial Parts. Molecules 2014, 19, 20382-20390.

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