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Molecules 2014, 19(12), 19594-19609; doi:10.3390/molecules191219594

The Effect of Lycii Radicis Cortex Extract on Bone Formation in Vitro and in Vivo

1
Department of Medical Genetics, Ajou University School of Medicine, Suwon 443-721, Korea
2
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 443-721, Korea
3
Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon 443-721, Korea
4
Clinical Trial Center, Ajou University Medical Center, Suwon 443-721, Korea
5
Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion, Suwon 443-721, Korea
6
Korea Food Research Institute, Seongnam 463-746, Korea
7
Dongwoodang Pharmacy Co., Ltd., Yeongchen 770-864, Korea
8
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon 443-721, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 October 2014 / Revised: 19 November 2014 / Accepted: 20 November 2014 / Published: 26 November 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Osteoporosis is a common skeletal disease caused by decreased bone mass; it enhances the risk of bone fracture. This study aimed to discover novel herbal extract(s) for the treatment of osteoporosis. We screened 64 ethanol extracts of edible plants native to Korea for their ability to increase the cellular proliferation and differentiation of two osteoblastic cell lines: C3H10T1/2 and MC3T3-E1. We selected a Lycii Radicis Cortex (LRC), Lycium Chinese root bark as the primary candidate. Treatment with LRC extract showed enhanced alkaline phosphatase activity and increased expression of bone metabolic markers Alpl, Runx2, and Bglap genes in both osteoblastic cell lines. There was no effect on the osteoclastic differentiation of primary-cultured monocytes from the mouse bone marrows. Furthermore, the study examined the effect of LRC extract in vivo in ovariectomizd (OVX) mice for 8 weeks and 16 weeks, respectively. Bone mineral density (BMD) was significantly higher in LRC extract-administered group than in the non-LRC-administered OVX control group. The results indicated that LRC extract prevented the OVX-induced BMD loss in mice via promoting the differentiation of osteoblast linage cells. These results suggest that LRC extract may be a good natural herbal medicine candidate for the treatment of osteoporosis. View Full-Text
Keywords: herbal medicine; osteoporosis; Lycii Radicis Cortex; osteoblast; ovariectomized mice; bone mineral density herbal medicine; osteoporosis; Lycii Radicis Cortex; osteoblast; ovariectomized mice; bone mineral density
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, E.; Jin, H.-S.; Cho, D.-Y.; Kim, J.; Kim, M.-C.; Choi, C.W.; Jin, Y.; Lee, J.-W.; Park, J.-H.; Chung, Y.-S.; Huh, D.; Jeong, S.-Y. The Effect of Lycii Radicis Cortex Extract on Bone Formation in Vitro and in Vivo. Molecules 2014, 19, 19594-19609.

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