Polylactide Conjugates of Camptothecin with Different Drug Release Abilities
AbstractCamptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems—important delivery systems for anti-cancer agents. View Full-Text
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Oledzka, E.; Horeglad, P.; Gruszczyńska, Z.; Plichta, A.; Nałęcz-Jawecki, G.; Sobczak, M. Polylactide Conjugates of Camptothecin with Different Drug Release Abilities. Molecules 2014, 19, 19460-19470.
Oledzka E, Horeglad P, Gruszczyńska Z, Plichta A, Nałęcz-Jawecki G, Sobczak M. Polylactide Conjugates of Camptothecin with Different Drug Release Abilities. Molecules. 2014; 19(12):19460-19470.Chicago/Turabian Style
Oledzka, Ewa; Horeglad, Paweł; Gruszczyńska, Zuzanna; Plichta, Andrzej; Nałęcz-Jawecki, Grzegorz; Sobczak, Marcin. 2014. "Polylactide Conjugates of Camptothecin with Different Drug Release Abilities." Molecules 19, no. 12: 19460-19470.