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Molecules 2014, 19(12), 19460-19470; doi:10.3390/molecules191219460

Polylactide Conjugates of Camptothecin with Different Drug Release Abilities

1
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland
2
Centre of New Technologies, University of Warsaw, Banacha 2c, Warsaw 02-097, Poland
3
Chair of Polymer Chemistry and Technology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland
4
Department of Environmental Health Science, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, Warsaw 02-097, Poland
5
Chair of Chemistry, Department of Organic Chemistry, Faculty of Materials Science and Design, Kazimierz Pulaski University of Technology and Humanities in Radom, Chrobrego 27, Radom 26-600, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 October 2014 / Revised: 14 November 2014 / Accepted: 18 November 2014 / Published: 25 November 2014
(This article belongs to the Special Issue Prodrugs)
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Abstract

Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems—important delivery systems for anti-cancer agents. View Full-Text
Keywords: macromolecular conjugates; biodegradable polymers; camptothecin; drug delivery systems; controlled release macromolecular conjugates; biodegradable polymers; camptothecin; drug delivery systems; controlled release
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MDPI and ACS Style

Oledzka, E.; Horeglad, P.; Gruszczyńska, Z.; Plichta, A.; Nałęcz-Jawecki, G.; Sobczak, M. Polylactide Conjugates of Camptothecin with Different Drug Release Abilities. Molecules 2014, 19, 19460-19470.

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