Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides
AbstractA series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods. Molecular structures of three salinomycin derivatives in the solid state were determined using single crystal X-ray method. All compounds obtained were screened for their antiproliferative activity against various human cancer cell lines as well as against the most problematic bacteria strains such as methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MRSE), and Mycobacterium tuberculosis. Novel salinomycin derivatives exhibited potent anticancer activity against drug-resistant cell lines. Additionally, two N-benzyl amides of salinomycin revealed interesting antibacterial activity. The most active were N-benzyl amides of SAL substituted at -ortho position and the least anticancer active derivatives were those substituted at the -para position. View Full-Text
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Antoszczak, M.; Maj, E.; Napiórkowska, A.; Stefańska, J.; Augustynowicz-Kopeć, E.; Wietrzyk, J.; Janczak, J.; Brzezinski, B.; Huczyński, A. Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides. Molecules 2014, 19, 19435-19459.
Antoszczak M, Maj E, Napiórkowska A, Stefańska J, Augustynowicz-Kopeć E, Wietrzyk J, Janczak J, Brzezinski B, Huczyński A. Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides. Molecules. 2014; 19(12):19435-19459.Chicago/Turabian Style
Antoszczak, Michał; Maj, Ewa; Napiórkowska, Agnieszka; Stefańska, Joanna; Augustynowicz-Kopeć, Ewa; Wietrzyk, Joanna; Janczak, Jan; Brzezinski, Bogumil; Huczyński, Adam. 2014. "Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides." Molecules 19, no. 12: 19435-19459.