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Molecules 2014, 19(11), 19172-19179; doi:10.3390/molecules191119172

Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis

1
Research Center of Ginseng and Medicinal Materials, 41 Dinh Tien Hoang, District 1, Ho Chi Minh City 700-00, Vietnam
2
Faculty of Chemistry, University of Science, Vietnam National University-HoChiMinh City, 227 Nguyen Van Cu, District 5, Ho Chi Minh City 227-01, Vietnam
*
Authors to whom correspondence should be addressed.
Received: 6 October 2014 / Revised: 14 November 2014 / Accepted: 17 November 2014 / Published: 19 November 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

A series of Lycopodium alkaloids, namely lycosquarosine A (1), acetylaposerratinine (2), huperzine A (3), huperzine B (4), 8α-hydrophlemariurine B (5), and huperzinine (6), has been isolated from Vietnamese Huperzia squarrosa. Among them, lycosquarosine A (1) is the new metabolite of the natural source. Lycosquarosine A completely inhibited AChE activity in a dose dependent manner with an IC50 value of 54.3 μg/mL, while acetylaposerratinine (2) showed stronger inhibitory activity than 1 with an IC50 value of 15.2 µg/mL. This result indicates that these alkaloids may be a potent source of AChE inhibitors. View Full-Text
Keywords: Huperzia squarrosa; Lycopodiaceae; lycosquarosine A; acetylcholinesterase; Lycopodium alkaloids Huperzia squarrosa; Lycopodiaceae; lycosquarosine A; acetylcholinesterase; Lycopodium alkaloids
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MDPI and ACS Style

Chuong, N.N.; Huong, N.T.T.; Hung, T.M.; Luan, T.C. Anti-Cholinesterase Activity of Lycopodium Alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis. Molecules 2014, 19, 19172-19179.

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