Next Article in Journal
Classification of Frankfurters by FT-Raman Spectroscopy and Chemometric Methods
Previous Article in Journal
TOMBU and COMBU as Novel Uronium-Type Peptide Coupling Reagents Derived from Oxyma-B
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(11), 18966-18979; doi:10.3390/molecules191118966

The Diterpenes Ovoideal A–G from Tirpitzia ovoidea

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road, Beijing 100191, China
*
Author to whom correspondence should be addressed.
Received: 23 September 2014 / Revised: 4 November 2014 / Accepted: 5 November 2014 / Published: 18 November 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [399 KB, uploaded 20 November 2014]   |  

Abstract

Seven new diterpenes, named ovoideal A (1), B (2), C (3), D (4), E (5), F (6) and G (7), have been isolated along with eleven known diterpenes 818 from the petroleum ether soluble fraction of an ethanol extract of the aerial parts of Tirpitzia ovoidea. The structures of the new compounds were elucidated primarily by 1D and 2D NMR spectroscopy, as well as by the HR-ESI-MS spectrometry. All compounds were isolated from the Linaceae family for the first time. The in vitro cytotoxic activity of compounds 1, 35, 818 was evaluated against the Hela, HepG2 and K562 cell lines. Among them, compounds 3, 9, 11, 12, 13, 14, 15, 17, 18 showed moderate inhibitory activities. View Full-Text
Keywords: Tirpitzia ovoidea; Linaceae; diterpene; cytotoxic activity Tirpitzia ovoidea; Linaceae; diterpene; cytotoxic activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Su, D.; Yang, X.-Y.; Feng, X.; Shang, M.-Y.; Cai, S.-Q. The Diterpenes Ovoideal A–G from Tirpitzia ovoidea. Molecules 2014, 19, 18966-18979.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top