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Molecules 2014, 19(11), 18025-18032; doi:10.3390/molecules191118025

Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.

1
Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
2
College of Food and Biological Engineering, Jimei University, Xiamen 361021, China
3
Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
4
Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 19 October 2014 / Revised: 30 October 2014 / Accepted: 30 October 2014 / Published: 5 November 2014
(This article belongs to the Collection Bioactive Compounds)
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Abstract

An unusual meroterpenoid, dysidinoid A (1), was isolated from the South China Sea sponge Dysidea sp. Its structure was elucidated by extensive spectroscopic methods including HRESIMS and 2D NMR, and its absolute configuration was determined by single-crystal X-ray diffraction analysis. Dysidinoid A (1) is the first meroterpenoid from Nature bearing a 9,4-friedodrime skeleton and a 2,5-dionepyrrole unit. Dysidinoid A (1) showed potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) with MIC90 values of 8.0 μg/mL against both. View Full-Text
Keywords: dysidinoid A; meroterpenoid; anti-MRSA; Dysidea; marine sponge dysidinoid A; meroterpenoid; anti-MRSA; Dysidea; marine sponge
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jiao, W.-H.; Li, J.; Liu, Q.; Xu, T.-T.; Shi, G.-H.; Yu, H.-B.; Yang, F.; Han, B.-N.; Li, M.; Lin, H.-W. Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.. Molecules 2014, 19, 18025-18032.

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