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Molecules 2014, 19(11), 17202-17220; doi:10.3390/molecules191117202

ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells

1
Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil
2
Departamento de Farmácia, Universidade Federal de Juiz de Fora (UFJF), Campus Governador Valadares, Av. Dr. Raimundo Monteiro de Rezende, 330, Centro, 35010-177 Governador Valadares, Brazil
3
Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), 31270-901 Belo Horizonte, Brazil
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 25 September 2014 / Revised: 15 October 2014 / Accepted: 15 October 2014 / Published: 27 October 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

2-Acetylpyridine acetylhydrazone (H2AcMe), 2-benzoylpyridine acetylhydrazone (H2BzMe) and complexes [Cu(H2AcMe)Cl2] (1) and [Cu(H2BzMe)Cl2] (2) were assayed for their cytotoxicity against wild type p53 U87 and mutant p53 T98 glioma cells, and against MRC-5 fibroblast cells. Compounds 1 and 2 proved to be more active than the corresponding hydrazones against U87, but not against T98 cells. Compound 1 induced higher levels of ROS than H2AcMe in both glioma cell lines. H2AcMe and 1 induced lower levels of ROS in MRC5 than in U87 cells. Compound 2 induced lower levels of ROS in MRC5 than in T98 cells. The cytotoxic effect of 1 in U87 cells could be related to its ability to provoke the release of ROS, suggesting that the cytotoxicity of 1 might be somehow p53 dependent. View Full-Text
Keywords: pyridine-derived hydrazones; copper(II) complexes; cytotoxicity; glioma cells; ROS generation pyridine-derived hydrazones; copper(II) complexes; cytotoxicity; glioma cells; ROS generation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Recio Despaigne, A.A.; Da Silva, J.G.; da Costa, P.R.; dos Santos, R.G.; Beraldo, H. ROS-Mediated Cytotoxic Effect of Copper(II) Hydrazone Complexes against Human Glioma Cells. Molecules 2014, 19, 17202-17220.

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