A New Urease Inhibitor from Viola betonicifolia
AbstractUrease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases. View Full-Text
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Muhammad, N.; Saeed, M.; Khan, A.; Adhikari, A.; Wadood, A.; Khan, K.M.; De Feo, V. A New Urease Inhibitor from Viola betonicifolia. Molecules 2014, 19, 16770-16778.
Muhammad N, Saeed M, Khan A, Adhikari A, Wadood A, Khan KM, De Feo V. A New Urease Inhibitor from Viola betonicifolia. Molecules. 2014; 19(10):16770-16778.Chicago/Turabian Style
Muhammad, Naveed; Saeed, Muhammad; Khan, Ajmal; Adhikari, Achyut; Wadood, Abdul; Khan, Khalid M.; De Feo, Vincenzo. 2014. "A New Urease Inhibitor from Viola betonicifolia." Molecules 19, no. 10: 16770-16778.