Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase
AbstractNicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium stores. Starting with 2′-deoxy-2′-fluoroarabinosyl-β-nicotinamide adenine dinucleotide (ara-F NAD), a series of NAD analogues were synthesized and their activities to inhibit CD38 NAD glycohydrolase (NADase) were evaluated. The adenosine-modified analogues showed potent inhibitory activities, among which 2′-deoxy-2′-fluoroarabinosyl-β-nicotinamide guanine dinucleotide (ara-F NGD) was the most effective one. The structure-activity relationship of NAD analogues was also discussed. View Full-Text
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Wang, S.; Zhu, W.; Wang, X.; Li, J.; Zhang, K.; Zhang, L.; Zhao, Y.-J.; Lee, H.C.; Zhang, L. Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase. Molecules 2014, 19, 15754-15767.
Wang S, Zhu W, Wang X, Li J, Zhang K, Zhang L, Zhao Y-J, Lee HC, Zhang L. Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase. Molecules. 2014; 19(10):15754-15767.Chicago/Turabian Style
Wang, Shengjun; Zhu, Wenjie; Wang, Xuan; Li, Jianguo; Zhang, Kehui; Zhang, Liangren; Zhao, Yong-Juan; Lee, Hon C.; Zhang, Lihe. 2014. "Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase." Molecules 19, no. 10: 15754-15767.