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Molecules 2014, 19(1), 740-755; doi:10.3390/molecules19010740

Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents

1
Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt
2
Department of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Cairo 12622, Egypt
3
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, Madrid 28040, Spain
*
Author to whom correspondence should be addressed.
Received: 17 November 2013 / Revised: 16 December 2013 / Accepted: 17 December 2013 / Published: 8 January 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

Two series of naphtho[1,8-ef][1,4]diazepines and pyrrolo[1,2-a]perimidines were prepared starting from 1,8-diaminonaphthalene and hydrazonoyl chlorides. The structures of the products were determined on the basis of their spectral data and elemental analyses. The mechanism of formation of such products was also discussed. The prepared compounds were screened for their antitumor activity against three cell lines, namely, MCF-7, TK-10 and UACC-62, and some derivatives showed promising activity.
Keywords: 1,8-diaminonaphthalene; naphtho[1,8-ef][1,4]diazepines; pyrrolo[1,2-a] perimidines; hydrazonoyl chloride; antitumor activity 1,8-diaminonaphthalene; naphtho[1,8-ef][1,4]diazepines; pyrrolo[1,2-a] perimidines; hydrazonoyl chloride; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Farghaly, T.A.; Abbas, E.M.H.; Dawood, K.M.; El-Naggar, T.B.A. Synthesis of 2-Phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-Arylhydrazono)pyrrolo[1,2-a]perimidines as Antitumor Agents. Molecules 2014, 19, 740-755.

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