Molecules 2014, 19(1), 538-549; doi:10.3390/molecules19010538
Article

Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs

1,2email, 1email and 1,* email
Received: 14 October 2013; in revised form: 2 December 2013 / Accepted: 3 December 2013 / Published: 3 January 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The pharmacokinetics of N,N-bis(2-mercapatoethly)-N',N'-diethylenediamine (BMEDA), a molecule that can form a chelate with rhenium-188 (188Re) to produce the 188Re-BMEDA-liposomes, was studied. In this work, beagles received a single injection of BMEDA, at doses of 1, 2, or 5 mg/kg; the concentration of BMEDA in the beagles’ plasma was then analyzed and determined by liquid chromatography-mass spectrometry/mass spectrometry. Based on the pharmacokinetic parameters of BMEDA, we found that male and female animals shared similar patterns indicating that the pharmacokinetics of BMEDA is independent of gender differences. In addition, the pharmacokinetics of BMEDA was seen to be non-linear because the increase of mean AUC0–t and AUC0–∞ values tend to be greater than dose proportional while the mean Vss and CL values of BMEDA appeared to be dose dependent. The information on the pharmacokinetics of BMEDA generated from this study will serve as a basis to design appropriate pharmacology and toxicology studies for future human use.
Keywords: acute toxicity; radiopharmaceutical; BMEDA; 188Re-BMEDA-liposome; pharmacokinetics
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MDPI and ACS Style

Chang, C.-H.; Liu, S.-Y.; Lee, T.-W. Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs. Molecules 2014, 19, 538-549.

AMA Style

Chang C-H, Liu S-Y, Lee T-W. Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs. Molecules. 2014; 19(1):538-549.

Chicago/Turabian Style

Chang, Chih-Hsien; Liu, Si-Yen; Lee, Te-Wei. 2014. "Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs." Molecules 19, no. 1: 538-549.

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