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Open AccessCommunication
Molecules 2014, 19(1), 525-537; doi:10.3390/molecules19010525

Saccharide Substituted Zinc Phthalocyanines: Optical Properties, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging for Sentinel Lymph Nodes

Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
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Received: 20 November 2013 / Revised: 24 December 2013 / Accepted: 24 December 2013 / Published: 3 January 2014
(This article belongs to the Special Issue Fluorescent Probes)
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Abstract

Saccharide-substituted zinc phthalocyanines, [2,9(10),16(17),23(24)-tetrakis((1-(β-D-glucose-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)phthalocyaninato]zinc(II) and [2,9(10), 16(17),23(24)-tetrakis((1-(β-D-lactose-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)phthalocyaninato] zinc(II), were evaluated as novel near infrared fluorescence agents. Their interaction with bovine serum albumin was investigated by fluorescence and circular dichroism spectroscopy and isothermal titration calorimetry. Near infrared imaging for sentinel lymph nodes in vivo was performed using nude mice as models. Results show that saccharide- substituted zinc phthalocyanines have favourable water solubility, good optical stability and high emission ability in the near infrared region. The interaction of lactose-substituted phthalocyanine with bovine serum albumin displays obvious differences to that of glucose- substituted phthalocyanine. Moreover, lactose-substituted phthalocyanine possesses obvious imaging effects for sentinel lymph nodes in vivo.
Keywords: near infrared fluorescence probe; sentinel lymph node imaging; zinc phthalocyanine; saccharide; bovine serum albumin near infrared fluorescence probe; sentinel lymph node imaging; zinc phthalocyanine; saccharide; bovine serum albumin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lu, L.; Lv, F.; Cao, B.; He, X.; Liu, T. Saccharide Substituted Zinc Phthalocyanines: Optical Properties, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging for Sentinel Lymph Nodes. Molecules 2014, 19, 525-537.

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