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Molecules 2014, 19(1), 525-537; doi:10.3390/molecules19010525
Communication

Saccharide Substituted Zinc Phthalocyanines: Optical Properties, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging for Sentinel Lymph Nodes

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Received: 20 November 2013; in revised form: 24 December 2013 / Accepted: 24 December 2013 / Published: 3 January 2014
(This article belongs to the Special Issue Fluorescent Probes)
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Abstract: Saccharide-substituted zinc phthalocyanines, [2,9(10),16(17),23(24)-tetrakis((1-(β-D-glucose-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)phthalocyaninato]zinc(II) and [2,9(10), 16(17),23(24)-tetrakis((1-(β-D-lactose-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)phthalocyaninato] zinc(II), were evaluated as novel near infrared fluorescence agents. Their interaction with bovine serum albumin was investigated by fluorescence and circular dichroism spectroscopy and isothermal titration calorimetry. Near infrared imaging for sentinel lymph nodes in vivo was performed using nude mice as models. Results show that saccharide- substituted zinc phthalocyanines have favourable water solubility, good optical stability and high emission ability in the near infrared region. The interaction of lactose-substituted phthalocyanine with bovine serum albumin displays obvious differences to that of glucose- substituted phthalocyanine. Moreover, lactose-substituted phthalocyanine possesses obvious imaging effects for sentinel lymph nodes in vivo.
Keywords: near infrared fluorescence probe; sentinel lymph node imaging; zinc phthalocyanine; saccharide; bovine serum albumin near infrared fluorescence probe; sentinel lymph node imaging; zinc phthalocyanine; saccharide; bovine serum albumin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lu, L.; Lv, F.; Cao, B.; He, X.; Liu, T. Saccharide Substituted Zinc Phthalocyanines: Optical Properties, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging for Sentinel Lymph Nodes. Molecules 2014, 19, 525-537.

AMA Style

Lu L, Lv F, Cao B, He X, Liu T. Saccharide Substituted Zinc Phthalocyanines: Optical Properties, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging for Sentinel Lymph Nodes. Molecules. 2014; 19(1):525-537.

Chicago/Turabian Style

Lu, Li; Lv, Feng; Cao, Bo; He, Xujun; Liu, Tianjun. 2014. "Saccharide Substituted Zinc Phthalocyanines: Optical Properties, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging for Sentinel Lymph Nodes." Molecules 19, no. 1: 525-537.


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