Next Article in Journal
Antioxidant Properties and Hyphenated HPLC-PDA-MS Profiling of Chilean Pica Mango Fruits (Mangifera indica L. Cv. piqueño)
Next Article in Special Issue
EGF Receptor-Dependent Mechanism May be Involved in the Tamm–Horsfall Glycoprotein-Enhanced PMN Phagocytosis via Activating Rho Family and MAPK Signaling Pathway
Previous Article in Journal
Synthesis, Anticancer Activity and UPLC Analysis of the Stability of Some New Benzimidazole-4,7-dione Derivatives
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(1), 414-437; https://doi.org/10.3390/molecules19010414

A New Chemical Approach to Human ABO Histo-Blood Group Type 2 Antigens

1
Department of Applied Bioorganic Chemistry, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan
2
Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan
*
Author to whom correspondence should be addressed.
Received: 13 December 2013 / Revised: 24 December 2013 / Accepted: 25 December 2013 / Published: 31 December 2013
(This article belongs to the Special Issue Oligosaccharides and Glyco-Conjugates)
View Full-Text   |   Download PDF [402 KB, uploaded 18 June 2014]   |  

Abstract

A new chemical approach to synthesizing human ABO histo-blood type 2 antigenic determinants was developed. N-Phthaloyl-protected lactosaminyl thioglycoside derived from lactulose via the Heyns rearrangement was employed to obtain a type 2 core disaccharide. Use of this scheme lowered the overall number of reaction steps. Stereoselective construction of the α-galactosaminide/galactoside found in A- and B-antigens, respectively, was achieved by using a unique di-tert-butylsilylene-directed α-glycosylation method. The proposed synthetic scheme provides an alternative to existing procedures for preparing ABO blood group antigens. View Full-Text
Keywords: blood group antigen; oligosaccharide; glycosylation; Heyns rearrangement blood group antigen; oligosaccharide; glycosylation; Heyns rearrangement
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Hara, A.; Imamura, A.; Ando, H.; Ishida, H.; Kiso, M. A New Chemical Approach to Human ABO Histo-Blood Group Type 2 Antigens. Molecules 2014, 19, 414-437.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top