- freely available
Molecules 2014, 19(1), 1273-1285; doi:10.3390/molecules19011273
Published: 20 January 2014
Abstract: Oxylipins or oxidized fatty acids are a group of molecules found to play a role in signaling in many different cell types. These fatty acid derivatives have ancient evolutionary origins as signaling molecules and are ideal candidates for inter-kingdom communication. This review discusses examples of the ability of organisms from different kingdoms to “listen” and respond to oxylipin signals during interactions. The interactions that will be looked at are signaling between animals and plants; between animals and fungi; between animals and bacteria and between plants and fungi. This will aid in understanding these interactions, which often have implications in ecology, agriculture as well as human and animal health.
Until recently the study of signaling and response in different kingdoms of life developed independently from each other, with little regard for the similarities between the different kingdoms. However, it has become apparent that elements of signaling are shared by different kingdoms [1,2,3,4]. It is speculated that many of these are ancestral traits or that some may be due to convergent evolution, horizontal gene transfer or ancient symbiosis . These shared signals come into play when there is interaction between members of the different kingdoms (ranging from mutually beneficial interactions such as symbiosis, to ones harmful to at least one member such as parasitism), and include plant defenses against herbivores and plant pathogens, animal defenses against pathogenic microbes and parasites as well as the influence of bacterial and fungal quorum sensing molecules on members of the different kingdoms. Schultz and Appel  speculated that the ability of interacting organisms to communicate through shared signal systems may provide an adaptive advantage and that there are a limited number of these signaling systems. When one starts to examine the shared signals involved in these interactions, it becomes evident that a group of signals based on fatty acids are often shared between different kingdoms . Enzymatically modified lipids have ancient evolutionary origins as signaling molecules  and are ideal candidates for communication with and manipulation of interacting parties.
The aim of this review is to discuss examples of the ability of organisms from different kingdoms to “listen” and respond to fatty acid signals, specifically oxidized fatty acid, during interactions. This will aid in understanding these interactions, which often have implications in ecology, agriculture as well as human and animal health.
2. Inter-Kingdom Signaling between Animals and Plants
Most of the study of inter-kingdom signaling between animals and plants focuses on the plant’s response to herbivores, such as insects. These responses are often due to hormones that are shared between the different kingdoms . In addition, it is well known that plants and animals produce a range of similar oxidized fatty acids (oxylipins/eicosanoids). These oxidized fatty acids are considered central to inter-kingdom interactions involving plants.
One of the most important plant oxylipins is jasmonic acid (Figure 1a). It regulates several important physiological processes in plants including induced defense against herbivores . It is produced from α-linolenic acid upon wounding and leads to the production of toxic compounds as protective measure. Although it mainly serves as an internal signaling molecule, Li and co-workers  reported that jasmonic acid, ingested by the corn ear worm (Helicoverpa zea), activates transcription of four cytochrome P450 genes involved in metabolism of plant toxins. This ability to “listen” to plant oxylipin signals protects H. zea against the host plant’s defenses. Plants also have the ability to produce autoxidation products, the phytoprostanes, from α-linolenic acid. These include phytoprostane E1 , phytoprostane F1  phytoprostane A1 and phytoprostane B1  (Figure 1b). Of specific interest is the occurrence of these phytoprostanes in pollen, where they are known collectively as pollen-associated lipid mediators (PALMs) . When pollen comes into contact with mucous membranes of animals these PALMs are released. Certain PALMs are immunostimulatory in humans, activating polymorphonuclear granulocytes, neutrophils and eosinophils [11,12]. In addition, phytoprostane E1 modulates cytokine (IL-12) production by dendritic cells through a PPAR-γ dependent pathway that leads to inhibition of NF-κB activation. This results in an increased Th 2 response, such as inflammation, mediated by the release of Th 2 cytokines (e.g., IL-4), as well as activation of eosinophils, mediated by IL-5, which is characteristic of pollen allergy .
Plants can also perceive fatty acid signals from animals. Volicitin (Figure 2a) is a conjugate of 17-hydroxy linolenic acid and L-glutamine produced and secreted by caterpillars . It comes into contact with the plant when the caterpillars feed and results in the production of plant protective volatile compounds in some plants [14,15,16]. It was also shown that plants wounded and treated with caterpillar regurgitant, containing volicitin, increased their foliar tannin concentration without a negative effect on growth . This is not the only oxidized fatty acid based molecule with potential inter-kingdom signaling activity found in insect regurgitant. Schultz and Appel  showed that tannin production by plants after wounding, is suppressed when prostaglandin E2 (Figure 2b, an animal derived arachidonic acid metabolite) is added to the wound. They also showed that the same effect was observed when the wounded plants were treated with regurgitant of the gypsy moth or forest tent caterpillars, speculated to contain prostaglandin E2. Unfortunately the exact composition of the caterpillar regurgitant was not determined.
This inter-kingdom signaling between plants and animals is also found between diatoms (unicellular algae) and small crustaceans, the copepods, that feed on them. Several diatoms (e.g., Pseudo-nitzchia delicatissima, Chaetoceros spp., Thalassiosira rotula, Cerataulina pelagica) produce a range of oxylipins, including hydroxy fatty acids. Many of these oxylipins have a negative impact on copepod egg production, hatching success, and development of the offspring, similar to the more common diatom toxins, the polyunsaturated aldehydes, although the precise mechanism is still unknown [18,19,20]. It is speculated that oxylipins as signaling molecules are so fundamental to survival of plants, where they play a crucial role in defense, that they have been conserved through evolution .
3. Inter-Kingdom Signaling between Animals and Fungi
Animals produce an range of oxygenated C20 fatty acids, the eicosanoids, which include prostaglandins, thromboxanes, prostacyclins, leukotrienes, lipoxins, hepoxilins, hydro(pero)xy fatty acids, hydroxylated and epoxy fatty acids [21,22]. They are produced by cyclooxygenases , lipoxygenases , cytochrome P450s [22,25], or nonenzymatic pathways  from fatty acid precursors, dihomo-γ-linolenic acid, arachidonic acid, eicosapentaenoic acid  and docosahexaenoic acid . The immunomodulatory properties of eicosanoids have been studied intensively in mammalian cells with a single eicosanoid capable of having pleiotropic functions [28,29]. These effects are mainly due to the existence of multiple G-protein-coupled receptors (GPCRs), known as guanine nucleotide regulatory proteins, for each lipid species [21,29]. The activated trimeric G-proteins affect the concentrations of the second messengers, cyclic AMP (cAMP), or intracellular ions such as K+.
In fungi, the precursors for oxylipin production are usually oleic acid, linoleic acid and α-linolenic acid . However, it is known that pathogenic yeasts can produce oxylipins from arachidonic acid, which they may acquire from the infected host cell (Figure 3) . In the genus Candida, several potentially pathogenic species (i.e., C. albicans, C. dubliniensis, C. glabrata and C. tropicalis) can produce prostaglandin E2 (PGE2) [32,33,34]. Candida albicans can also produce prostaglandin D2 (PGD2), prostaglandin PGF2α (PGF2α) and leukotrienes (LTB4, cysteinyl leukotrienes) from arachidonic acid . Cryptococcus neoformans, is also capable of producing PGE2, PGD2, PGF2α and leukotrienes [32,35] and Paracoccidioides brasiliensis can use exogenous or endogenous arachidonic acid to produce prostaglandin Ex (possibly PGE2) [36,37]. Another important fungal respiratory pathogen, Aspergillus fumigatus and Aspergillus nidulans contain cyclooxygenase like enzymes and are also capable of producing arachidonic acid metabolites [38,39]. These included PGE2, 6-keto-prostaglandin F1α, PGF2α, isoprostanes and thromboxane B2, most of which decrease the pulmonary function of the host. Candida albicans can also produce eicosanoids from eicosapentaenoic acid and docosahexanoic acid (Figure 3) . One of these eicosanoids, resolvin E1, is a potent anti-inflammatory lipid that attenuates neutrophil migration during the resolution phase of inflammation. Is has been suggested that low levels of resolvin E1, produced by commensal C. albicans, would dampen the adaptive immune response and protect the commensal yeast from the host’s immune response.
Since both host and pathogen are capable of producing eicosanoids during an infection these signals may be involved in a complex inter-kingdom dialogue between animal (host) and fungus. The enhanced production of prostaglandins and leukotrienes by pathogenic yeasts and the biological effects of prostaglandins on the host immune system may lead to the intracellular survival followed by chronic and disseminated infections [36,38,40,41,42,43]. It is also tempting to speculate that fungal spores contain lipid mediators that are released upon contact with mucous membranes and may elicit responses associated with disease and/or allergies in a similar manner to PALMs in plant pollen.
In addition, host derived eicosanoids have an effect on yeast cells. Prostaglandin E2 induces morphogenesis (i.e., yeast-to-hyphae transition) in C. albicans and C. dubliniensis, probably by increasing cellular cAMP levels [34,44,45]. Similarly thromboxane B2 (TXB2) also increases morphogenesis in C. albicans .
4. Inter-Kingdom Signaling between Animals and Bacteria
The lung secretions of cystic fibrosis (CF) sufferers contain a wide range of inflammatory and anti-inflammatory oxidized fatty acids, including arachidonic acid metabolites . It is known that several bacterial species can infect CF lungs and that these microbes may contribute to the production of these lipid mediators . Pseudomonas aeruginosa is the most important bacterial colonizer of CF lungs . Interestingly, it was found that a virulence factor in P. aeruginosa, the type III secretion effector molecule, ExoU, induced the release of arachidonic acid from human endothelial cells . In addition, this bacterium has the ability to convert arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE) (Figure 4a) through a secreted 15-lipoxygenase . 15-HETE can activate several mammalian signaling pathways, including MAP kinases and at high concentrations it can activate the PPAR-γ pathway, which plays an important anti-inflammatory role via inhibition of NF-κB expression . Although the role of 15-HETE in airway epithelium is not clear, there has been suggestions that it could play a role in mucous production and bronchial contractibility .
Another bacterium often associated with the lungs of adult CF patients is Stenotrophomonas maltophilia . Weil and co-workers  showed that this bacterium can produce 3(R)-hydroxy fatty acids from a range of precursors by a process analogous to β-oxidation. Although they did not test arachidonic acid as a precursor, if their conclusions are applied to the oxidation of arachidonic acid, the product would be 3(R)-hydroxyeicosatetraenoic acid (3-HETE). Mammalian cyclooxygenase 2 (COX-2) can oxygenate 3-HETE to 3-OH-prostaglandin E2 (Figure 4b) which is a more potent inducer of proinflammtory interleukin 6 (IL-6) mRNA expression than PGE2 . It is interesting to note that IL-6 is one of the important inflammatory markers in patients with CF, especially during episodes of acute pulmonary exacerbations [55,56] and levels of this cytokine is correlated with loss of fat-free mass in these patients . Whether the increased level of IL-6 in these patients is influenced by Stenotrophomonas maltophilia infection still needs to be determined.
5. Inter-Kingdom Signaling between Plants and Fungi
The roles of oxylipins in plant-fungal interactions were reviewed by Christensen and Kolomiets . Plant oxylipins can influence reproduction in fungi. Examples include the plant lipoxygenase products 9-hydroperoxy octadecadienoic acid and 13- hydroperoxy octadecadienoic acid (Figure 5) that can induce conidial development in several Aspergillus species. At low concentration 9-hydroperoxyoctadecadienoic results in sexual spore formation instead of conidial development in Aspergillus nidulans . These oxylipins also influence mycotoxin production by Aspergillus, with 9-hydroperoxyoctadecadienoic acid stimulating toxin production and 13-hydroperoxyoctadecadienoic acid inhibiting toxin production. Evidence suggests that this regulation is transcriptional . It is further speculated that 9-lipoxygenase derived plant oxylipins act as fungal signals that regulate pathogenicity, spore and toxin production by several plant pathogenic Aspergillus species and Fusarium verticilloides . The jasmonic acid metabolite, methyl jasmonate, was also found to regulate reproduction and toxin production in fungi. It decreases sporulation and aflatoxin production in Aspergillus flavus  and stimulates aflatoxin production in Aspergillus parasiticus .
Brodhagen and co-workers  also demonstrated that the communication between plants and fungi is not one way, but that fungal oxylipins (e.g., 8-hydroxyoctadecenoic acid and 8-hydroxy-octadecadienoic acid) (Figure 6) also influence expression of plant genes, i.e., plant lipoxygenase genes. The plant pathogenic fungus, Lasiodiplodia theobromae is able to produce the plant oxylipin jasmonic acid . The release of fungal jasmonic acid during infection leads to the inhibition of the salicylic acid mediated defense system in the plant, contributing to infection by this fungus.
Recent evidence has also shown the occurrence and possible role of oxylipins during beneficial plant-fungus interactions. Products of the 9-lipoxygenase pathway that normally serve as plant defense compounds, were also found to be involved in regulation of symbiotic fungal growth during arbuscular mycorrhiza development in tomatoes . Another interesting example is the endophytic fungus, Fusarium incarnatum, found inside the embryos of the mangrove tree Aegiceras corniculatum . This fungus can produce archetypal plant defense oxylipins (coriolic acid, didehydrocoriolic acid and 12,13-epoxy-11-hydroxyoctadecenoic acid) from linoleic acid by the action of a desaturase and a 13-lipoxygenase (Figure 7). These authors speculated that these fungal oxylipins may serve to protect the embryos, during dispersal by sea and so improve the chances of reproduction.
Oxidized fatty acids are present in diverse kingdoms of life, and organisms from these different kingdoms have the ability to produce, detect and respond to these inter-kingdom signaling molecules. These responses are varied and may be involved in pathogenesis or in benign, symbiotic interactions. As such they play important roles in ecology, agriculture and medicine. Although there are still many unanswered questions regarding the specific signals and their mechanism of action, understanding this and other inter-kingdom signals will increase our understanding of these interactions.
Conflicts of Interest
The authors declare no conflict of interest.
- Schultz, J.C. Shared signals and the potential for phylogenetic espionage between plants and animals. Integr. Comp. Biol. 2002, 42, 454–462, doi:10.1093/icb/42.3.454.
- Schultz, J.C.; Appel, H.M. Cross-kingdom cross-talk: Hormones shared by plants and insects and their herbivores. Ecology 2004, 85, 70–77, doi:10.1890/02-0704.
- Savchenko, T.; Walley, J.W.; Chehab, E.W.; Xiao, Y.; Kaspi, R.; Pye, M.F.; Mohamed, M.E.; Lazarus, C.M.; Bostock, R.M.; Dehesh, K. Arachidonic acid: An evolutionary conserved signaling molecule modulates plant stress signaling networks. Plant Cell 2010, 22, 3193–3205, doi:10.1105/tpc.110.073858.
- Hernandez-Oñate, M.A.; Esquivel-Naranjo, E.U.; Mendoza-Mendoza, A.; Stewart, A.; Herrera-Estrella, A.H. An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development. Proc. Natl. Acad. Sci. USA 2012, 109, 14918–14923, doi:10.1073/pnas.1209396109.
- Haas-Stapleton, E.J.; Lu, Y.; Hong, S.; Arita, M.; Favoreto, S.; Nigam, S.; Serhan, C.N.; Agabian, N. Candida albicans modulates host defence by biosynthesizing the pro-resolving mediator resolvin E1. PLoS One 2007, 12, e1316.
- Weber, H. Fatty acid-derived signals in plants. Trends Plant. Sci. 2002, 7, 217–224, doi:10.1016/S1360-1385(02)02250-1.
- Li, X.; Schuler, M.A.; Berenbaum, M.R. Jasmonate and salicylate induce expression of herbivore cytochrome 450 genes. Nature 2002, 419, 712–715, doi:10.1038/nature01003.
- Parchmann, S.; Meuller, M.J. Evidence for the formation of dinor isoprostanes E1 from linolenic acid in plants. J. Biol. Chem. 1998, 273, 32650–32655, doi:10.1074/jbc.273.49.32650.
- Imbusch, R.; Meuller, M.J. Formation of isoprostane F2-like compounds (phytoprostanes F1) from α-linolenic acid in plants. Free Radic. Biol. Med. 2000, 28, 720–726, doi:10.1016/S0891-5849(00)00154-4.
- Traidl-Hoffmann, C.; Mariani, V.; Hochrein, H.; Karg, K.; Wagner, H.; Ring, J.; Meuller, M.J.; Jakob, T.; Behrendt, H. Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J. Exp. Med. 2005, 20, 627–636.
- Gilles, S.; Mariani, V.; Bryce, M.; Meuller, M.J.; Ring, J.; Behrendt, H.; Jakob, T.; Traidl-Hoffmann, C. Pollen allergens do not come alone: Pollen associated lipid mediators (PALMS) shift the human immune systems towards a Th2-dominated response. Allergy Asthma Clin. Immunol. 2009, 5, 3, doi:10.1186/1710-1492-5-3.
- Traidl-Hoffmann, C.; Kasche, A.; Jakob, T.; Huger, M.; Plötz, S.; Feussner, I.; Ring, J.; Behrendt, H. Lipid mediators from pollen act as chemoattractants and activators of polymorphonuclear granulocytes. J. Allergy Clin. Immunol. 2002, 109, 831–838, doi:10.1067/mai.2002.124655.
- Gilles, S.; Mariani, V.; Bryce, M.; Meuller, M.J.; Ring, J.; Jakob, T.; Pastore, S.; Behrendt, H.; Traidl-Hoffmann, C. Pollen derived E1 phytoprostanes signal via PPAR-γ and NF-κB dependent mechanisms. J. Immunol. 2009, 182, 6653–6658, doi:10.4049/jimmunol.0802613.
- Alborn, H.T.; Turlings, T.C.J.; Jones, T.H.; Stenhagen, G.; Loughrin, J.H.; Tumlinson, J.H. An elicitor of plant volatiles from beet armyworm oral secretion. Science 1997, 276, 945–949, doi:10.1126/science.276.5314.945.
- Turlings, T.C.J.; Alborn, H.T.; Loughrin, J.H.; Tumlinson, J.H. Volicitin, an elicitor of maize volatiles in oral secretions of Spodoptera exigua: Isolation and bioactivity. J. Chem. Ecol. 2000, 26, 189–202, doi:10.1023/A:1005449730052.
- Mori, N.; Yoshinaga, N. Function and evolutionary diversity of fatty acid amino acid conjugates in insects. J. Plant Interact. 2011, 6, 103–107, doi:10.1080/17429145.2010.544412.
- Häring, D.A.; Huber, M.J.; Suter, D.; Edwards, P.J.; Lüscher, A. Plant enemy-derived elicitors increase the foliar tannin concentration of Onobrychis viciifolia without a trade-off to growth. Ann. Bot. 2008, 102, 979–987, doi:10.1093/aob/mcn189.
- Fontana, A.; d’Ippolito, G.; Cutignano, A.; Romano, G.; Lamari, N.; Massa Gallucci, A.; Cimino, A.; Miralto, G.; Ianora, A. A metabolic mechanism for the detrimental effect of marine diatoms on zooplankton grazers. ChemBioChem 2007, 8, 1810–1818, doi:10.1002/cbic.200700269.
- Ianora, A.; Romano, G.; Carotenuto, Y.; Esposito, F.; Roncalli, V.; Buttino, I.; Miralto, A. Impact of the diatom oxylipin 15S-HEPE on the reproductive success of the copepod Temora stylifera. Hydrobiologia 2011, 666, 265–275, doi:10.1007/s10750-010-0420-7.
- Ianora, A.; Miralto, A. Toxigenic effects of diatoms on grazers, phytoplankton and other microbes: A review. Ecotoxicology 2010, 19, 493–511.
- Smith, W.L. The eicosanoids and their biochemical mechanism of action. Biochem. J. 1989, 259, 315–324.
- Zeldin, D.C. Epoxygenase pathways of arachidonic acid metabolism. J. Biol. Chem. 2001, 276, 36059–36062.
- Murakami, M.; Kudo, I. Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prog. Lipid Res. 2004, 43, 3–35.
- Henderson, W.R. The role of leukotrienes in inflammation. Ann. Intern. Med. 1994, 121, 684–697.
- Carroll, M.A.; McGiff, J.C. A new class of lipid mediators: Cytochrome P450 arachidonate metabolites. Thorax 2000, 55, S13–S16.
- Buczynski, M.W.; Dumlao, D.S.; Dennis, E.D. Thematic review: An integrated omics analysis of eicosanoid biology. J. Lipid Res. 2009, 50, 1015–1038.
- Serhan, C.N.; Arita, M.; Hong, S.; Gotlinger, K. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids 2004, 39, 1125–1132.
- Funk, C.D. Prostaglandins and leukotrienes: Advances in eicosanoid biology. Science 2001, 294, 1871–1875.
- Hatae, N.; Sugimoto, Y.; Ichikawa, A. Prostaglandin receptors: Advances in the study of EP3 receptor signalling. J. Biochem. 2002, 131, 781–783.
- Tsitsigiannis, D.I.; Keller, N.P. Oxylipins as developmental and host-fungal communication signals. Trends Microbiol. 2007, 15, 109–118.
- Ells, R.; Kock, J.L.F.; Albertyn, J.; Pohl, C.H. Arachidonic acid metabolites of pathogenic yeasts. Lipids Health Dis. 2012, 11, doi:10.1186/1476-511X-11-100.
- Noverr, M.C.; Phare, S.M.; Toews, G.B.; Coffey, M.J.; Huffnagle, G.B. Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins. Infect. Immun. 2001, 69, 2957–2963, doi:10.1128/IAI.69.5.2957-2963.2001.
- Shiraki, Y.; Ishbashi, Y.; Hiruma, M.; Nashikawa, A.; Ikeda, S. Candida albicans abrogates the expression of interferon-γ-inducible protein-10 in human keratinocytes. FEMS Immunol. Med. Microbiol. 2008, 54, 122–128, doi:10.1111/j.1574-695X.2008.00457.x.
- Ells, R.; Kock, J.L.F.; Albertyn, J.; Kemp, G.; Pohl, C.H. Effect of inhibitors of arachidonic acid metabolism on prostaglandin E2 production by Candida albicans and Candida dubliniensis. Med. Microbiol. Immunol. 2011, 200, 23–28.
- Noverr, M.C.; Toews, G.B.; Huffnagle, G.B. Production of prostaglandins and leukotrienes by pathogenic fungi. Infect. Immun. 2002, 70, 400–402, doi:10.1128/IAI.70.1.400-402.2002.
- Bordon, A.P.; Dias-Melicio, L.A.; Acorci, M.J.; Calvi, S.A.; Peraçoli, M.T.S.; Soares, A.M.V.C. Prostalandin E2 inhibits Paracoccidioides brasiliensis killing by human monocytes. Microbes Infect. 2007, 9, 744–747, doi:10.1016/j.micinf.2007.02.019.
- Biondo, G.A.; Dias-Melicio, L.A.; Bordon-Graciani, A.P.; Acorci-Valério, M.J.; Soares, A.M.V.C. Paracoccidioides brasiliensis uses endogenous and exogenous arachidonic acid for PGEx production. Mycopathologia 2010, 170, 123–130, doi:10.1007/s11046-010-9301-x.
- Tsitsigiannis, D.I.; Bok, J.; Andes, D.; Nielsen, K.F.; Frisvad, J.C.; Keller, N.P. Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence. Infect. Immun. 2005, 73, 4548–4559, doi:10.1128/IAI.73.8.4548-4559.2005.
- Kupfahl, C.; Tsikas, D.; Niemann, J.; Geginat, G.; Hof, H. Production of prostaglandins, isoprostanes and thromboxane by Aspergillus fumigatus: Identification by gas chromatography-tandem mass spectrometry and quantification by enzyme immunoassay. Mol. Immunol. 2012, 49, 621–627, doi:10.1016/j.molimm.2011.10.010.
- Betz, M.; Fox, B.S. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 1991, 146, 108–113.
- Soares, A.M.V.C.; Calvi, S.A.; Peraçoli, M.T.S.; Fernandez, A.C.; Dias, L.A.; Dos Anjos, A.R. Modulatory effect of prostaglandins on human monocyte activiation for killing of high- and low-virulence strains of Paracoccidioides brasiliensis. Immunology 2001, 102, 480–485, doi:10.1046/j.1365-2567.2001.01179.x.
- Noverr, M.C.; Erb-Downward, J.R.; Huffnagle, G.B. Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes. Clin. Microbiol. Rev. 2003, 16, 517–533, doi:10.1128/CMR.16.3.517-533.2003.
- Shibata, Y.; Hendersen, R.A.; Honda, I.; Nakamura, R.M.; Myrvik, Q.N. Splenic PGE2-releasing macrophages regulate Th1 and Th2 immune responses in mice treated with heat-killed BCG. J. Leukoc. Biol. 2005, 78, 1281–1290, doi:10.1189/jlb.0605321.
- Kalo-Klein, A.; Witkin, S.S. Prostaglandin E2 enhances and gamma-interferon inhibits germ tube formation in Candida albicans. Infect. Immun. 1990, 58, 260–262.
- Noverr, M.C.; Huffnagle, G.B. Regulation of Candida albicans morphogenesis by fatty acid metabolites. Infect. Immun. 2004, 72, 6206–6210, doi:10.1128/IAI.72.11.6206-6210.2004.
- Yang, J.; Eiserich, J.P.; Cross, C.E.; Morrissey, B.M.; Hammock, B.D. Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radic. Biol. Med. 2012, 53, 160–171, doi:10.1016/j.freeradbiomed.2012.05.001.
- Eiserich, J.P.; Yang, J.; Morrissey, B.M.; Hammock, B.D.; Cross, C.E. Omics approaches in cystic fibrosis research: A focus on oxylipin profiling in airway secretions. Ann. N. Y. Acad. Sci. 2012, 1259, 1–9.
- Ciofu, O.; Hansen, C.R.; Høiby, N. Respiratory bacterial infections in cystic fibrosis. Curr. Opin. Pulm. Med. 2013, 19, 251–258, doi:10.1097/MCP.0b013e32835f1afc.
- Saliba, A.M.; Nascimento, D.O.; Silva, M.C.A.; Assis, M.C.; Gayer, C.R.M.; Raymond, B.; Coelho, M.G.P.; Marques, E.A.; Touqui, L.; Albano, R.M.; et al. Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU. Cell. Microbiol. 2005, 7, 1811–1822, doi:10.1111/j.1462-5822.2005.00635.x.
- Vance, R.E.; Hong, S.; Gronert, K.; Serhan, C.N.; Mekalanos, J.J. The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc. Natl. Acad. Sci. USA 2004, 101, 2135–2139, doi:10.1073/pnas.0307308101.
- Kühn, H.; O’Donnell, V.B. Inflammation and immune regulation by 12/15-lipoxygenases. Prog. Lipid Res. 2006, 45, 334–356, doi:10.1016/j.plipres.2006.02.003.
- Kühn, H.; Walther, M.; Kuban, R.J. Mammalian arachidonate 15-lipoxygenases, structure, function and biological implications. Prostaglandins Other Lipid Mediat. 2002, 68, 263–290.
- Weil, K.; Gruber, P.; Heckel, F.; Harmsen, D.; Schreier, P. Selective (R)-3-hydroxylation of FA by Stenotrophomonas maltophilia. Lipids 2002, 37, 317–323, doi:10.1007/s11745-002-0897-z.
- Ciccoli, R.; Sahi, S.; Singh, S.; Prakash, H.; Zafiriou, M.-P.; Ishdorj, G.; Kock, J.L.F.; Nigam, S. Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids. Biochem. J. 2005, 390, 737–747, doi:10.1042/BJ20041995.
- Tirelli, A.S.; Colombo, C.; Torresani, E.; Fortunato, F.; Biffi, A.; Cariani, L.; Daccò, V.; Carbone, A.; Edefonti, A.; Paglialonga, F.; et al. Effects of treatment in the levels of circulating cytokines and growth factors in cystic fibrosis and dialyzed patients by multi-analytical determination with a biochip array platform. Cytokine 2013, 62, 413–420, doi:10.1016/j.cyto.2013.03.029.
- Beiersdorf, N.; Schien, M.; Hentschel, J.; Pfister, W.; Markert, U.R.; Mainz, J.G. Soluble inflammation markers in nasal lavage from CF patients and healthy controls. J. Cystic Fibrosis 2013, 12, 249–257, doi:10.1016/j.jcf.2012.08.015.
- King, S.J.; Nyulasi, I.B.; Bailey, M.; Kotsimbos, T.; Wilson, J.W. Loss of fat-free mass over four years in adult cystic fibrosis is associated with high serum interleukin-6 levels but not tumour necrosis factor-alpha. Clin. Nutrit. 2013, doi:10.1016/j.clnu.2013.04.012.
- Christensen, S.A.; Kolomiets, M.V. The lipid language of plant-fungal interactions. Fungal Genet. Biol. 2011, 48, 4–14, doi:10.1016/j.fgb.2010.05.005.
- Calvo, A.; Hinze, L.; Gardner, H.; Keller, N.P. Sporogenic effect of polyunsaturated fatty acids on Aspergillus ssp. development. Appl. Environ. Microbiol. 1999, 65, 3668–3673.
- Burow, G.B.; Nesbitt, T.C.; Dunlap, J.; Keller, N.P. Seed lipoxygenase products modulate Aspergillus mycotoxin biosynthesis. Mol. Plant.Microbe Interact. 1997, 10, 380–387, doi:10.1094/MPMI.19220.127.116.110.
- Gao, X.Q.; Kolomiets, M.V. Host-derived lipids and oxylipins are crucial signals in modulating mycotoxin production by fungi. Toxin Rev. 2009, 28, 79–88, doi:10.1080/15569540802420584.
- Goodrich-Tanrikulu, M.; Mahoney, N.E.; Rodriques, S.B. The plant-growth regulator methyl jasmonate inhibits aflatoxin production by Aspergillus flavus. Microbiology 1995, 141, 2831–2837, doi:10.1099/13500872-141-11-2831.
- Vergopoulou, S.; Galanopoulou, D.; Markaki, P. Methyl jasmonate stimulates aflatoxin B-1 biosynthesis by Aspergillus parasiticus. J. Agric. Food Chem. 2001, 49, 3494–3498, doi:10.1021/jf010074+.
- Brodhagen, M.; Tsitsigiannis, D.I.; Hornung, E.; Goebel, C.; Feussner, I.; Keller, N.P. Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem. Mol. Microbiol. 2008, 67, 378–391.
- Tsukada, K.; Takahashi, K.; Nabeta, K. Biosynthesis of jasmonic acid in a plant pathogenic fungus, Lasiodiplodia theobromae. Phytochemistry 2010, 71, 2019–2023, doi:10.1016/j.phytochem.2010.09.013.
- Morcillo, R.J.L.; Ocampo, J.A.; García Garrido, J.M. Plant 9-lox oxylipin metabolism in response to arbuscular mycorrhiza. Plant. Signal. Behav. 2012, 7, 1–5, doi:10.4161/psb.7.1.18574.
- Ding, L.; Peschel, G.; Hertwick, C. Biosynthesis of archetypal plant self-defensive oxylipins by an endophytic fungus in mangrove embryos. ChemBioChem 2012, 13, 2661–2664, doi:10.1002/cbic.201200544.
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).