Molecules 2014, 19(1), 1286-1301; doi:10.3390/molecules19011286
Article

Synthesis of 4-Methoxybenzoylhydrazones and Evaluation of Their Antiglycation Activity

1,2,* email, 1,3, 4, 1,2, 1,3, 4 and 1,4
Received: 17 December 2013; in revised form: 31 December 2013 / Accepted: 2 January 2014 / Published: 21 January 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [295 KB, uploaded 18 June 2014]
Abstract: A series of 4-methoxybenzoylhydrazones 130 was synthesized and the structures of the synthetic derivatives elucidated by spectroscopic methods. The compounds showed a varying degree of antiglycation activity, with IC50 values ranging between 216.52 and 748.71 µM, when compared to a rutin standard (IC50 = 294.46 ± 1.50 µM). Compounds 1 (IC50 = 216.52 ± 4.2 µM), 3 (IC50 = 289.58 ± 2.64 µM), 6 (IC50 = 227.75 ± 0.53 µM), 7 (IC50 = 242.53 ± 6.1) and 11 (IC50 = 287.79 ± 1.59) all showed more activity that the standard, and these compounds have the potential to serve as possible leads for drugs to inhibit protein glycation in diabetic patients. A preliminary SAR study was performed.
Keywords: 4-methoxybenzoylhydrazones; antiglycation activity; rutin; AGEs; protein glycation inhibition; diabetes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Taha, M.; Naz, H.; Rasheed, S.; Ismail, N.H.; Rahman, A.A.; Yousuf, S.; Choudhary, M.I. Synthesis of 4-Methoxybenzoylhydrazones and Evaluation of Their Antiglycation Activity. Molecules 2014, 19, 1286-1301.

AMA Style

Taha M, Naz H, Rasheed S, Ismail NH, Rahman AA, Yousuf S, Choudhary MI. Synthesis of 4-Methoxybenzoylhydrazones and Evaluation of Their Antiglycation Activity. Molecules. 2014; 19(1):1286-1301.

Chicago/Turabian Style

Taha, Muhammad; Naz, Humera; Rasheed, Saima; Ismail, Nor H.; Rahman, Aqilah A.; Yousuf, Sammer; Choudhary, Muhammad I. 2014. "Synthesis of 4-Methoxybenzoylhydrazones and Evaluation of Their Antiglycation Activity." Molecules 19, no. 1: 1286-1301.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert