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Molecules 2014, 19(1), 122-138;

Bioactive Compounds from the Roots of Asiasarum heterotropoides

KM-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea
Author to whom correspondence should be addressed.
Received: 14 November 2013 / Revised: 13 December 2013 / Accepted: 16 December 2013 / Published: 23 December 2013
(This article belongs to the Collection Bioactive Compounds)
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A new tetrahydrofuran lignan, (7S,8R,7'S,8'S)-3-methoxy-3',4'-methylenedioxy-7,9'-epoxylignane-4,7',9-triol (1), and 21 known compounds 222 were isolated from the roots of Asiasarum heterotropoides by chromatographic separation methods. The structures of all compounds 122 were elucidated by spectroscopic analysis including 1D- and 2D-NMR. Fourteen of these compounds (13, 7, 10, 1217, 19, 21, and 22) were isolated from this species in this study for the first time. All of the isolates were evaluated for their anticancer activities using in vitro assays. Among the 22 tested compounds, two (compounds 5 and 7) induced the downregulation of NO production, FOXP3 expression, and HIF-1α transcriptional activity. View Full-Text
Keywords: Asiasarum heterotropoides; aristolochiaceae; tetrahydrofuran lignan; cytotoxicity; nitric oxide; FOXP3; HIF-1α Asiasarum heterotropoides; aristolochiaceae; tetrahydrofuran lignan; cytotoxicity; nitric oxide; FOXP3; HIF-1α

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Lee, J.; Lee, Y.J.; Oh, S.-M.; Yi, J.-M.; Kim, N.S.; Bang, O.-S. Bioactive Compounds from the Roots of Asiasarum heterotropoides. Molecules 2014, 19, 122-138.

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