Open AccessThis article is
- freely available
Bioactive Compounds from the Roots of Asiasarum heterotropoides
KM-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea
* Author to whom correspondence should be addressed.
Received: 14 November 2013; in revised form: 13 December 2013 / Accepted: 16 December 2013 / Published: 23 December 2013
Abstract: A new tetrahydrofuran lignan, (7S,8R,7'S,8'S)-3-methoxy-3',4'-methylenedioxy-7,9'-epoxylignane-4,7',9-triol (1), and 21 known compounds 2–22 were isolated from the roots of Asiasarum heterotropoides by chromatographic separation methods. The structures of all compounds 1–22 were elucidated by spectroscopic analysis including 1D- and 2D-NMR. Fourteen of these compounds (1–3, 7, 10, 12–17, 19, 21, and 22) were isolated from this species in this study for the first time. All of the isolates were evaluated for their anticancer activities using in vitro assays. Among the 22 tested compounds, two (compounds 5 and 7) induced the downregulation of NO production, FOXP3 expression, and HIF-1α transcriptional activity.
Keywords: Asiasarum heterotropoides; aristolochiaceae; tetrahydrofuran lignan; cytotoxicity; nitric oxide; FOXP3; HIF-1α
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Lee, J.; Lee, Y.J.; Oh, S.-M.; Yi, J.-M.; Kim, N.S.; Bang, O.-S. Bioactive Compounds from the Roots of Asiasarum heterotropoides. Molecules 2014, 19, 122-138.
Lee J, Lee YJ, Oh S-M, Yi J-M, Kim NS, Bang O-S. Bioactive Compounds from the Roots of Asiasarum heterotropoides. Molecules. 2014; 19(1):122-138.
Lee, Jun; Lee, You J.; Oh, Se-Mi; Yi, Jin-Mu; Kim, No S.; Bang, Ok-Sun. 2014. "Bioactive Compounds from the Roots of Asiasarum heterotropoides." Molecules 19, no. 1: 122-138.