1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors
AbstractA series of 1H-2,3-dihydroperimidine derivatives was designed, synthesized, and evaluated as a new class of inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the micromolar range. Compounds 46 and 49 showed submicromolar inhibitory activity against PTP1B, and good selectivity (3.48-fold and 2.10-fold respectively) over T-cell protein tyrosine phosphatases (TCPTP). These results have provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Wang, W.-L.; Yang, D.-L.; Gao, L.-X.; Tang, C.-L.; Ma, W.-P.; Ye, H.-H.; Zhang, S.-Q.; Zhao, Y.-N.; Xu, H.-J.; Hu, Z.; Chen, X.; Fan, W.-H.; Chen, H.-J.; Li, J.-Y.; Nan, F.-J.; Li, J.; Feng, B. 1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors. Molecules 2014, 19, 102-121.
Wang W-L, Yang D-L, Gao L-X, Tang C-L, Ma W-P, Ye H-H, Zhang S-Q, Zhao Y-N, Xu H-J, Hu Z, Chen X, Fan W-H, Chen H-J, Li J-Y, Nan F-J, Li J, Feng B. 1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors. Molecules. 2014; 19(1):102-121.Chicago/Turabian Style
Wang, Wen-Long; Yang, Dong-Lin; Gao, Li-Xin; Tang, Chun-Lan; Ma, Wei-Ping; Ye, Hui-Hua; Zhang, Si-Qi; Zhao, Ya-Nan; Xu, Hao-Jie; Hu, Zhao; Chen, Xia; Fan, Wen-Hua; Chen, Hai-Jun; Li, Jing-Ya; Nan, Fa-Jun; Li, Jia; Feng, Bainian. 2014. "1H-2,3-Dihydroperimidine Derivatives: A New Class of Potent Protein Tyrosine Phosphatase 1B Inhibitors." Molecules 19, no. 1: 102-121.