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Molecules 2014, 19(1), 139-148; doi:10.3390/molecules19010139

Asymmetric Synthesis of 4,1-Benzoxazepine-2,5-Diones — Effect of the Halogen of (2S)-α-Haloacids

1
Ibn-e-Sina Block, Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan
2
Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia
3
Department of Physics, University of Sargodha, Sargodha 40100, Pakistan
*
Authors to whom correspondence should be addressed.
Received: 28 November 2013 / Revised: 12 December 2013 / Accepted: 16 December 2013 / Published: 23 December 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

Novel chiral 4,1-benzoxazepine-2,5-diones have been unusually synthesized in a single step by exploiting the chiral pool methodology. Substituted anthranilic acids afford N-acylanthranilic acids and (3R)-3-alkyl-4,1-benzoxazepines-2,5-dione upon coupling with α-chloroacids or α-bromoacids, respectively. View Full-Text
Keywords: (3R)-3-alkyl-4,1-benzoxazepine-2,5-diones; asymmetric synthesis; α-chloroacids; α-bromoacids; anthranilic acid; chiral pool methodology (3R)-3-alkyl-4,1-benzoxazepine-2,5-diones; asymmetric synthesis; α-chloroacids; α-bromoacids; anthranilic acid; chiral pool methodology
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Rubab, S.L.; Nisar, B.; Raza, A.R.; Ullah, N.; Tahir, M.N. Asymmetric Synthesis of 4,1-Benzoxazepine-2,5-Diones — Effect of the Halogen of (2S)-α-Haloacids. Molecules 2014, 19, 139-148.

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