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Molecules 2013, 18(9), 11144-11152; doi:10.3390/molecules180911144

An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs

1,2,†, 2,†, 2, 2, 2, 2,*  and 1,2,*
1 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China 2 Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 23 August 2013 / Revised: 3 September 2013 / Accepted: 4 September 2013 / Published: 11 September 2013
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An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
Keywords: anti-HBV; enantiopure; (R)-heteroarylpyrimidines; chiral separation; diastereomer anti-HBV; enantiopure; (R)-heteroarylpyrimidines; chiral separation; diastereomer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, X.-Y.; Xia, G.-Q.; Wang, X.-K.; Zheng, Z.-B.; Zhao, D.-M.; Zhao, G.-M.; Li, S. An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs. Molecules 2013, 18, 11144-11152.

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