Molecules 2013, 18(9), 11144-11152; doi:10.3390/molecules180911144
Article

An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs

1 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China 2 Department of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 23 August 2013; in revised form: 3 September 2013 / Accepted: 4 September 2013 / Published: 11 September 2013
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Abstract: An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
Keywords: anti-HBV; enantiopure; (R)-heteroarylpyrimidines; chiral separation; diastereomer

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MDPI and ACS Style

Yang, X.-Y.; Xia, G.-Q.; Wang, X.-K.; Zheng, Z.-B.; Zhao, D.-M.; Zhao, G.-M.; Li, S. An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs. Molecules 2013, 18, 11144-11152.

AMA Style

Yang X-Y, Xia G-Q, Wang X-K, Zheng Z-B, Zhao D-M, Zhao G-M, Li S. An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs. Molecules. 2013; 18(9):11144-11152.

Chicago/Turabian Style

Yang, Xiu-Yan; Xia, Guang-Qiang; Wang, Xiao-Kui; Zheng, Zhi-Bing; Zhao, Dong-Mei; Zhao, Guo-Ming; Li, Song. 2013. "An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs." Molecules 18, no. 9: 11144-11152.

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