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Molecules 2013, 18(9), 11144-11152; doi:10.3390/molecules180911144
Article

An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs

1,2,†, 2,†, 2, 2, 2, 2,*  and 1,2,*
Received: 23 August 2013 / Revised: 3 September 2013 / Accepted: 4 September 2013 / Published: 11 September 2013
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Abstract

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
Keywords: anti-HBV; enantiopure; (R)-heteroarylpyrimidines; chiral separation; diastereomer anti-HBV; enantiopure; (R)-heteroarylpyrimidines; chiral separation; diastereomer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, X.-Y.; Xia, G.-Q.; Wang, X.-K.; Zheng, Z.-B.; Zhao, D.-M.; Zhao, G.-M.; Li, S. An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs. Molecules 2013, 18, 11144-11152.

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