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Molecules 2013, 18(9), 10397-10403; doi:10.3390/molecules180910397

Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning 530023, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 1 July 2013 / Revised: 25 August 2013 / Accepted: 26 August 2013 / Published: 28 August 2013
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [234 KB, uploaded 18 June 2014]   |  


Twelve phenolics, including the three new compounds balanophonin C (1), balanophonin D (2), balanophonin E (3), were isolated from the seeds of Lithocarpus pachylepis. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 19 were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 and showed moderate inhibitory activities, with IC50 values ranging from 10.9 to 34.7 μM. View Full-Text
Keywords: Fagaceae; Lithocarpus pachylepis A Camus; phenolics; anti-inflammatory activities Fagaceae; Lithocarpus pachylepis A Camus; phenolics; anti-inflammatory activities

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xie, Y.; Ma, G.; Wei, H.; Yuan, J.; Wu, H.; Zhou, X.; Yang, J.; Xu, X. Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis. Molecules 2013, 18, 10397-10403.

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