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Molecules 2013, 18(9), 10397-10403; doi:10.3390/molecules180910397
Article

Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis

1,†
,
1,†
,
2
,
3
,
1
,
3
,
1
 and
1,*
1 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China 2 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China 3 National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning 530023, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 1 July 2013 / Revised: 25 August 2013 / Accepted: 26 August 2013 / Published: 28 August 2013
(This article belongs to the Section Metabolites)
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Abstract

Twelve phenolics, including the three new compounds balanophonin C (1), balanophonin D (2), balanophonin E (3), were isolated from the seeds of Lithocarpus pachylepis. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 19 were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 and showed moderate inhibitory activities, with IC50 values ranging from 10.9 to 34.7 μM.
Keywords: Fagaceae; Lithocarpus pachylepis A Camus; phenolics; anti-inflammatory activities Fagaceae; Lithocarpus pachylepis A Camus; phenolics; anti-inflammatory activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Xie, Y.; Ma, G.; Wei, H.; Yuan, J.; Wu, H.; Zhou, X.; Yang, J.; Xu, X. Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis. Molecules 2013, 18, 10397-10403.

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