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Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, National Development and Reform Commission, Guangxi Botanical Garden of Medicinal Plant, Nanning 530023, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 1 July 2013; in revised form: 25 August 2013 / Accepted: 26 August 2013 / Published: 28 August 2013
Abstract: Twelve phenolics, including the three new compounds balanophonin C (1), balanophonin D (2), balanophonin E (3), were isolated from the seeds of Lithocarpus pachylepis. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1–9 were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 and showed moderate inhibitory activities, with IC50 values ranging from 10.9 to 34.7 μM.
Keywords: Fagaceae; Lithocarpus pachylepis A Camus; phenolics; anti-inflammatory activities
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MDPI and ACS Style
Xie, Y.; Ma, G.; Wei, H.; Yuan, J.; Wu, H.; Zhou, X.; Yang, J.; Xu, X. Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis. Molecules 2013, 18, 10397-10403.
Xie Y, Ma G, Wei H, Yuan J, Wu H, Zhou X, Yang J, Xu X. Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis. Molecules. 2013; 18(9):10397-10403.
Xie, Yong; Ma, Guoxu; Wei, Hua; Yuan, Jingquan; Wu, Haifeng; Zhou, Xiaolei; Yang, Junshan; Xu, Xudong. 2013. "Three New Phenolics and Other Constituents from the Seeds of Lithocarpus pachylepis." Molecules 18, no. 9: 10397-10403.