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Molecules 2013, 18(9), 10108-10121; doi:10.3390/molecules180910108
Review

Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis

1
, 2
, 3,*  and 3,*
1 Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain 2 Division of Chemistry and Environmental Science, Faculty of Science and Engineering, Manchester Metropolitan University, John Dalton Extension, Oxford Road, Manchester M1 5GD, UK 3 Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, Alicante 03080, Spain
* Authors to whom correspondence should be addressed.
Received: 16 July 2013 / Revised: 9 August 2013 / Accepted: 15 August 2013 / Published: 22 August 2013
(This article belongs to the Special Issue Palladium Catalysts)
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Abstract

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-functionalization of aldehydes have been efficiently achieved employing this double-catalytic methodology.
Keywords: palladium; organocatalysis; asymmetric synthesis; dual activation; tandem reaction; allylation; fluorination; decarboxylative protonation palladium; organocatalysis; asymmetric synthesis; dual activation; tandem reaction; allylation; fluorination; decarboxylative protonation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fernández-Ibañez, M.Á.; Maciá, B.; Alonso, D.A.; Pastor, I.M. Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis. Molecules 2013, 18, 10108-10121.

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