Molecules 2013, 18(8), 9512-9530; doi:10.3390/molecules18089512
Review

The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures

1 Department of Chemistry, University of Pavia, Viale Taramelli, 10-27100 Pavia, Italy 2 INSTM Research Unit, University of Pavia, Viale Taramelli, 10-27100 Pavia, Italy 
Received: 1 July 2013; in revised form: 1 August 2013 / Accepted: 2 August 2013 / Published: 8 August 2013
(This article belongs to the Special Issue Advances in Click Chemistry)
PDF Full-text Download PDF Full-Text [418 KB, uploaded 8 August 2013 12:19 CEST]
Abstract: The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, known as the click reaction) is an established tool used for the construction of complex molecular architectures. Given its efficiency it has been widely applied for bioconjugation, polymer and dendrimer synthesis. More recently, this reaction has been utilized for the efficient formation of rigid or shape-persistent, preorganized macrocyclic species. This strategy also allows the installment of useful functionalities, in the form of polar and function-rich 1,2,3-triazole moieties, directly embedded in the macrocyclic structures. This review analyzes the state of the art in this context, and provides some elements of perspective for future applications.
Keywords: CuAAC; click chemistry; triazoles; macrocycles; chemical sensors; molecular recognition

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Pasini, D. The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures. Molecules 2013, 18, 9512-9530.

AMA Style

Pasini D. The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures. Molecules. 2013; 18(8):9512-9530.

Chicago/Turabian Style

Pasini, Dario. 2013. "The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures." Molecules 18, no. 8: 9512-9530.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert