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Molecules 2013, 18(8), 9512-9530; doi:10.3390/molecules18089512
Review

The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures

1,2
Received: 1 July 2013; in revised form: 1 August 2013 / Accepted: 2 August 2013 / Published: 8 August 2013
(This article belongs to the Special Issue Advances in Click Chemistry)
Download PDF [418 KB, uploaded 18 June 2014]
Abstract: The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, known as the click reaction) is an established tool used for the construction of complex molecular architectures. Given its efficiency it has been widely applied for bioconjugation, polymer and dendrimer synthesis. More recently, this reaction has been utilized for the efficient formation of rigid or shape-persistent, preorganized macrocyclic species. This strategy also allows the installment of useful functionalities, in the form of polar and function-rich 1,2,3-triazole moieties, directly embedded in the macrocyclic structures. This review analyzes the state of the art in this context, and provides some elements of perspective for future applications.
Keywords: CuAAC; click chemistry; triazoles; macrocycles; chemical sensors; molecular recognition CuAAC; click chemistry; triazoles; macrocycles; chemical sensors; molecular recognition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pasini, D. The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures. Molecules 2013, 18, 9512-9530.

AMA Style

Pasini D. The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures. Molecules. 2013; 18(8):9512-9530.

Chicago/Turabian Style

Pasini, Dario. 2013. "The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures." Molecules 18, no. 8: 9512-9530.


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