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Molecules 2013, 18(8), 9531-9549; doi:10.3390/molecules18089531
Review

Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology

1,2,3, 4,*  and 3,*
Received: 1 July 2013; in revised form: 3 August 2013 / Accepted: 5 August 2013 / Published: 8 August 2013
(This article belongs to the Special Issue Advances in Click Chemistry)
Download PDF [1424 KB, uploaded 18 June 2014]
Abstract: The alkyne-azide cycloaddition, popularly known as the “click” reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of disciplines, including biology. Some advantageous characteristics of this coupling include high efficiency, and adaptability to the environment in which the desired covalent linking of the alkyne and azide terminated moieties needs to be carried out. The efficient delivery of active pharmaceutical agents to specific organelles, employing nanocarriers developed through the use of “click” chemistry, constitutes a continuing topical area of research. In this review, we highlight important contributions click chemistry has made in the design of macromolecule-based nanomaterials for therapeutic intervention in mitochondria and lipid droplets.
Keywords: click chemistry; copper catalyzed alkyne-azide cycloaddition; drug delivery; lipid bodies; mitochondria click chemistry; copper catalyzed alkyne-azide cycloaddition; drug delivery; lipid bodies; mitochondria
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Avti, P.K.; Maysinger, D.; Kakkar, A. Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology. Molecules 2013, 18, 9531-9549.

AMA Style

Avti PK, Maysinger D, Kakkar A. Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology. Molecules. 2013; 18(8):9531-9549.

Chicago/Turabian Style

Avti, Pramod K.; Maysinger, Dusica; Kakkar, Ashok. 2013. "Alkyne-Azide “Click” Chemistry in Designing Nanocarriers for Applications in Biology." Molecules 18, no. 8: 9531-9549.



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