Molecules 2013, 18(8), 9488-9511; doi:10.3390/molecules18089488
Article

Efficient Synthesis of Boron-Containing α-Acyloxyamide Analogs via Microwave Irradiation

Received: 27 June 2013; in revised form: 2 August 2013 / Accepted: 5 August 2013 / Published: 8 August 2013
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this report, a Passerini three-component reaction utilizing boron-containing carboxylic acids or aldehydes is discussed. The reaction was carried out in water and facilitated by the use of microwave irradiation. This methodology allowed for the efficient formation of a broad range of boron-containing α-acyloxyamides under mild conditions within a short time. Two series of boron-containing α-acyloxyamides were synthesized and subsequently screened for cytotoxicity using the MTT cell viability assay. Two potential lead compounds were found to have potent activity against the HepG2 cancer cell line, demonstrating the potential of this methodology for use in the development of novel pharmaceuticals.
Keywords: boron; multicomponent reaction; Passerini reaction; HepG2
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MDPI and ACS Style

Chai, C.-C.; Liu, P.-Y.; Lin, C.-H.; Chen, H.-C.; Wu, Y.-C.; Chang, F.-R.; Pan, P.-S. Efficient Synthesis of Boron-Containing α-Acyloxyamide Analogs via Microwave Irradiation. Molecules 2013, 18, 9488-9511.

AMA Style

Chai C-C, Liu P-Y, Lin C-H, Chen H-C, Wu Y-C, Chang F-R, Pan P-S. Efficient Synthesis of Boron-Containing α-Acyloxyamide Analogs via Microwave Irradiation. Molecules. 2013; 18(8):9488-9511.

Chicago/Turabian Style

Chai, Chih-Cheng; Liu, Pin-Yi; Lin, Chia-Hung; Chen, Hsien-Chi; Wu, Yang-Chang; Chang, Fang-Rong; Pan, Po-Shen. 2013. "Efficient Synthesis of Boron-Containing α-Acyloxyamide Analogs via Microwave Irradiation." Molecules 18, no. 8: 9488-9511.

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