Molecules 2013, 18(8), 8845-8857; doi:10.3390/molecules18088845
Article

Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products

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Received: 21 May 2013; in revised form: 24 June 2013 / Accepted: 9 July 2013 / Published: 25 July 2013
(This article belongs to the Section Medicinal Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100µg/mL.
Keywords: Suzuki cross coupling; benzothiazoles; urease activity; nitric oxide scavenging activity
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MDPI and ACS Style

Gull, Y.; Rasool, N.; Noreen, M.; Nasim, F.-U.-H.; Yaqoob, A.; Kousar, S.; Rashid, U.; Bukhari, I.H.; Zubair, M.; Islam, M.S. Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products. Molecules 2013, 18, 8845-8857.

AMA Style

Gull Y, Rasool N, Noreen M, Nasim F-U-H, Yaqoob A, Kousar S, Rashid U, Bukhari IH, Zubair M, Islam MS. Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products. Molecules. 2013; 18(8):8845-8857.

Chicago/Turabian Style

Gull, Yasmeen; Rasool, Nasir; Noreen, Mnaza; Nasim, Faiz-ul-Hassan; Yaqoob, Asma; Kousar, Shazia; Rashid, Umer; Bukhari, Iftikhar H.; Zubair, Muhammad; Islam, Md. S. 2013. "Efficient Synthesis of 2-Amino-6-Arylbenzothiazoles via Pd(0) Suzuki Cross Coupling Reactions: Potent Urease Enzyme Inhibition and Nitric Oxide Scavenging Activities of the Products." Molecules 18, no. 8: 8845-8857.

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