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Molecules 2013, 18(7), 8518-8523; doi:10.3390/molecules18078518

Two New Chiratane-Type Triterpenoids from Swertia kouitchensis

1, 2, 3, 1 and 1,4,*
1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China 3 Shantou Institute for Drug Control, Shantou 515041, China 4 State Clinical Research Center of TCM, Hubei 430061, China
* Author to whom correspondence should be addressed.
Received: 5 June 2013 / Revised: 2 July 2013 / Accepted: 10 July 2013 / Published: 18 July 2013
(This article belongs to the Section Metabolites)
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Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 14 showed moderate inhibitory activity against the α-glucosidase (with IC50 values ranging from 1,812 to 2,027 μM).
Keywords: Swertia kouitchensis; diabetes; chiratane; triterpenoid; α-glucosidase Swertia kouitchensis; diabetes; chiratane; triterpenoid; α-glucosidase
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wan, L.-S.; Liu, T.-T.; Lin, X.-J.; Min, Q.-X.; Chen, J.-C. Two New Chiratane-Type Triterpenoids from Swertia kouitchensis. Molecules 2013, 18, 8518-8523.

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