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Two New Chiratane-Type Triterpenoids from Swertia kouitchensis
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Shantou Institute for Drug Control, Shantou 515041, China
State Clinical Research Center of TCM, Hubei 430061, China
* Author to whom correspondence should be addressed.
Received: 5 June 2013; in revised form: 2 July 2013 / Accepted: 10 July 2013 / Published: 18 July 2013
Abstract: Two rare new chiratane-type triterpenoids, kouitchenoids A and B (1, 2), together with oleanolic acid (3) and ursolic acid (4), were isolated from ethanol extract of Swertia kouitchensis. The new structures were determined by the analysis of MS and NMR data. In addition, compounds 1–4 showed moderate inhibitory activity against the α-glucosidase (with IC50 values ranging from 1,812 to 2,027 μM).
Keywords: Swertia kouitchensis; diabetes; chiratane; triterpenoid; α-glucosidase
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MDPI and ACS Style
Wan, L.-S.; Liu, T.-T.; Lin, X.-J.; Min, Q.-X.; Chen, J.-C. Two New Chiratane-Type Triterpenoids from Swertia kouitchensis. Molecules 2013, 18, 8518-8523.
Wan L-S, Liu T-T, Lin X-J, Min Q-X, Chen J-C. Two New Chiratane-Type Triterpenoids from Swertia kouitchensis. Molecules. 2013; 18(7):8518-8523.
Wan, Luo-Sheng; Liu, Ting-Ting; Lin, Xiao-Jun; Min, Qiu-Xia; Chen, Jia-Chun. 2013. "Two New Chiratane-Type Triterpenoids from Swertia kouitchensis." Molecules 18, no. 7: 8518-8523.