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Molecules 2013, 18(6), 7145-7159; doi:10.3390/molecules18067145
Review

Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology

 and *
Received: 20 May 2013; in revised form: 12 June 2013 / Accepted: 14 June 2013 / Published: 19 June 2013
(This article belongs to the Special Issue Advances in Click Chemistry)
Download PDF [679 KB, uploaded 18 June 2014]
Abstract: Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments. For glycobiology, bioorthogonal click chemistry has created a new method for glycan non-invasive imaging in living systems, selective metabolic engineering, and offered an elite chemical handle for biological manipulation and glycomics studies. Especially the [3 + 2] dipolar cycloadditions of azides with strained alkynes and the Staudinger ligation of azides and triarylphosphines have been widely used among the extant click reactions. This review focuses on the azide-based bioorthogonal click chemistry, describing the characteristics and development of these reactions, introducing some recent applications in glycobiology research, especially in glycan metabolic engineering, including glycan non-invasive imaging, glycomics studies and viral surface manipulation for drug discovery as well as other applications like activity-based protein profiling and carbohydrate microarrays.
Keywords: click chemistry; azide; bioorthogonal; glycosylation; glycobiology click chemistry; azide; bioorthogonal; glycosylation; glycobiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, X.; Zhang, Y. Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules 2013, 18, 7145-7159.

AMA Style

Zhang X, Zhang Y. Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules. 2013; 18(6):7145-7159.

Chicago/Turabian Style

Zhang, Xiu; Zhang, Yan. 2013. "Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology." Molecules 18, no. 6: 7145-7159.


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