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Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology
AbstractClick chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments. For glycobiology, bioorthogonal click chemistry has created a new method for glycan non-invasive imaging in living systems, selective metabolic engineering, and offered an elite chemical handle for biological manipulation and glycomics studies. Especially the [3 + 2] dipolar cycloadditions of azides with strained alkynes and the Staudinger ligation of azides and triarylphosphines have been widely used among the extant click reactions. This review focuses on the azide-based bioorthogonal click chemistry, describing the characteristics and development of these reactions, introducing some recent applications in glycobiology research, especially in glycan metabolic engineering, including glycan non-invasive imaging, glycomics studies and viral surface manipulation for drug discovery as well as other applications like activity-based protein profiling and carbohydrate microarrays.
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Zhang, X.; Zhang, Y. Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules 2013, 18, 7145-7159.View more citation formats
Zhang X, Zhang Y. Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules. 2013; 18(6):7145-7159.Chicago/Turabian Style
Zhang, Xiu; Zhang, Yan. 2013. "Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology." Molecules 18, no. 6: 7145-7159.
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