Abstract: d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.
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Zhu, H.; Zhao, J.; Lin, X.; Hong, Y.; Li, C.; Yang, Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules 2013, 18, 6425-6438.
Zhu H, Zhao J, Lin X, Hong Y, Li C, Yang Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules. 2013; 18(6):6425-6438.
Zhu, Hua; Zhao, Jun; Lin, Xinfeng; Hong, Ye; Li, Chun; Yang, Zhi. 2013. "Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging." Molecules 18, no. 6: 6425-6438.