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Molecules 2013, 18(6), 6425-6438; https://doi.org/10.3390/molecules18066425

Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging

1
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
2
Department of Experimental Diagnostic Imaging, Unit 59, the University of Texas MD Anderson Cancer Center,1515 Holcombe Boulevard, Houston, TX 77030, USA
3
China Institute of Atomic Energy, Beijing 102413, China
*
Authors to whom correspondence should be addressed.
Received: 26 March 2013 / Revised: 22 May 2013 / Accepted: 27 May 2013 / Published: 30 May 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis. View Full-Text
Keywords: indium-111; d-glucosamine; core-cross-linked polymeric micelles; glyco-nanoparticles; tumor imaging agent indium-111; d-glucosamine; core-cross-linked polymeric micelles; glyco-nanoparticles; tumor imaging agent
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Zhu, H.; Zhao, J.; Lin, X.; Hong, Y.; Li, C.; Yang, Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules 2013, 18, 6425-6438.

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