Next Article in Journal
Isoferulic Acid, a New Anti-Glycation Agent, Inhibits Fructose- and Glucose-Mediated Protein Glycation in Vitro
Previous Article in Journal
The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(6), 6425-6438; doi:10.3390/molecules18066425

Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging

1
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
2
Department of Experimental Diagnostic Imaging, Unit 59, the University of Texas MD Anderson Cancer Center,1515 Holcombe Boulevard, Houston, TX 77030, USA
3
China Institute of Atomic Energy, Beijing 102413, China
*
Authors to whom correspondence should be addressed.
Received: 26 March 2013 / Revised: 22 May 2013 / Accepted: 27 May 2013 / Published: 30 May 2013
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [960 KB, uploaded 18 June 2014]   |  

Abstract

d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.
Keywords: indium-111; d-glucosamine; core-cross-linked polymeric micelles; glyco-nanoparticles; tumor imaging agent indium-111; d-glucosamine; core-cross-linked polymeric micelles; glyco-nanoparticles; tumor imaging agent
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhu, H.; Zhao, J.; Lin, X.; Hong, Y.; Li, C.; Yang, Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules 2013, 18, 6425-6438.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top