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Molecules 2013, 18(6), 6425-6438; doi:10.3390/molecules18066425
Article

Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging

1, 2, 1, 3, 2,*  and 1,*
Received: 26 March 2013; in revised form: 22 May 2013 / Accepted: 27 May 2013 / Published: 30 May 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract: d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.
Keywords: indium-111; d-glucosamine; core-cross-linked polymeric micelles; glyco-nanoparticles; tumor imaging agent indium-111; d-glucosamine; core-cross-linked polymeric micelles; glyco-nanoparticles; tumor imaging agent
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhu, H.; Zhao, J.; Lin, X.; Hong, Y.; Li, C.; Yang, Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules 2013, 18, 6425-6438.

AMA Style

Zhu H, Zhao J, Lin X, Hong Y, Li C, Yang Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules. 2013; 18(6):6425-6438.

Chicago/Turabian Style

Zhu, Hua; Zhao, Jun; Lin, Xinfeng; Hong, Ye; Li, Chun; Yang, Zhi. 2013. "Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging." Molecules 18, no. 6: 6425-6438.



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