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Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
Department of Experimental Diagnostic Imaging, Unit 59, the University of Texas MD Anderson Cancer Center,1515 Holcombe Boulevard, Houston, TX 77030, USA
China Institute of Atomic Energy, Beijing 102413, China
* Authors to whom correspondence should be addressed.
Received: 26 March 2013; in revised form: 22 May 2013 / Accepted: 27 May 2013 / Published: 30 May 2013
Abstract: d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % of the injected dose per gram of tissue (%ID/g). Tumors were clearly delineated in both single-photon emission computed tomography (SPECT) and optical imaging. The results suggest that the prepared imaging tracer is a promising agent for tumor diagnosis.
Keywords: indium-111; d-glucosamine; core-cross-linked polymeric micelles; glyco-nanoparticles; tumor imaging agent
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MDPI and ACS Style
Zhu, H.; Zhao, J.; Lin, X.; Hong, Y.; Li, C.; Yang, Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules 2013, 18, 6425-6438.
Zhu H, Zhao J, Lin X, Hong Y, Li C, Yang Z. Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging. Molecules. 2013; 18(6):6425-6438.
Zhu, Hua; Zhao, Jun; Lin, Xinfeng; Hong, Ye; Li, Chun; Yang, Zhi. 2013. "Design, Synthesis and Evaluation of Dual-Modality Glyco-Nanoparticles for Tumor Imaging." Molecules 18, no. 6: 6425-6438.