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Molecules 2013, 18(5), 4917-4928; doi:10.3390/molecules18054917
Article

A Preliminary Study of the Effect of DBD Plasma and Osmolytes on T98G Brain Cancer and HEK Non-Malignant Cells

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Plasma Bioscience Research Center, Kwangwoon University, Seoul 139701, Korea
* Authors to whom correspondence should be addressed.
Received: 16 February 2013 / Revised: 11 April 2013 / Accepted: 23 April 2013 / Published: 25 April 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Non-thermal plasmas are emerging as a novel tool for the treatment of living tissues for biological and medical purpose. In this study, we described the effect of 4 min dielectric barrier discharge (DBD) plasma on both T98G cancer and HEK normal cell lines in the presence of different concentrations of osmolytes. This treatment strategy shows a specific inhibitory effect of a 240 s plasma exposure in the presence of osmolytes against T98G brain cancer cells only, but not on HEK normal cells. Based on these interesting properties of osmolytes, a non-thermal plasma appears to be a potential anticancer treatment strategy for different kinds of cancers in the presence of osmolytes.
Keywords: osmolytes; plasma; brain cancer cells; non-malignant cells osmolytes; plasma; brain cancer cells; non-malignant cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Kaushik, N.K.; Attri, P.; Kaushik, N.; Choi, E.H. A Preliminary Study of the Effect of DBD Plasma and Osmolytes on T98G Brain Cancer and HEK Non-Malignant Cells. Molecules 2013, 18, 4917-4928.

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