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Molecules 2013, 18(5), 4917-4928; doi:10.3390/molecules18054917
Article

A Preliminary Study of the Effect of DBD Plasma and Osmolytes on T98G Brain Cancer and HEK Non-Malignant Cells

* ,
,
 and *
Plasma Bioscience Research Center, Kwangwoon University, Seoul 139701, Korea
* Authors to whom correspondence should be addressed.
Received: 16 February 2013 / Revised: 11 April 2013 / Accepted: 23 April 2013 / Published: 25 April 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Non-thermal plasmas are emerging as a novel tool for the treatment of living tissues for biological and medical purpose. In this study, we described the effect of 4 min dielectric barrier discharge (DBD) plasma on both T98G cancer and HEK normal cell lines in the presence of different concentrations of osmolytes. This treatment strategy shows a specific inhibitory effect of a 240 s plasma exposure in the presence of osmolytes against T98G brain cancer cells only, but not on HEK normal cells. Based on these interesting properties of osmolytes, a non-thermal plasma appears to be a potential anticancer treatment strategy for different kinds of cancers in the presence of osmolytes.
Keywords: osmolytes; plasma; brain cancer cells; non-malignant cells osmolytes; plasma; brain cancer cells; non-malignant cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kaushik, N.K.; Attri, P.; Kaushik, N.; Choi, E.H. A Preliminary Study of the Effect of DBD Plasma and Osmolytes on T98G Brain Cancer and HEK Non-Malignant Cells. Molecules 2013, 18, 4917-4928.

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