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Molecules 2013, 18(4), 4689-4702; doi:10.3390/molecules18044689
Article

Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice

1,†, 2, 3, 2, 4,†,*  and 1,*
Received: 4 February 2013; in revised form: 17 April 2013 / Accepted: 18 April 2013 / Published: 19 April 2013
(This article belongs to the Section Metabolites)
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Abstract: Resveratrol (RES) is a well-known phytocompound and food component which has antioxidative and multifunctional bioactivities. However, there is limited evidence for the effects of RES on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of trans-RES on fatigue and ergogenic functions following physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered RES for 21 days at 0, 25, 50, and 125 mg/kg/day, which were respectively designated the vehicle, RES-25, RES-50, and RES-125 groups. The anti-fatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. The exhaustive swimming time of the RES-25 group (24.72 ± 7.35 min) was significantly (p = 0.0179) longer than that of vehicle group (10.83 ± 1.15 min). A trend analysis revealed that RES treatments increased the grip strength. RES supplementation also produced dose-dependent decreases in serum lactate and ammonia levels and CK activity and also an increase in glucose levels in dose-dependent manners after the 15-min swimming test. The mechanism was related to the increased energy utilization (as blood glucose), and decreased serum levels of lactate, ammonia, and CK. Therefore, RES could be a potential agent with an anti-fatigue pharmacological effect.
Keywords: resveratrol; anti-fatigue; exercise performance; forelimb grip strength; ammonia; creatine kinase resveratrol; anti-fatigue; exercise performance; forelimb grip strength; ammonia; creatine kinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, R.-E.; Huang, W.-C.; Liao, C.-C.; Chang, Y.-K.; Kan, N.-W.; Huang, C.-C. Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice. Molecules 2013, 18, 4689-4702.

AMA Style

Wu R-E, Huang W-C, Liao C-C, Chang Y-K, Kan N-W, Huang C-C. Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice. Molecules. 2013; 18(4):4689-4702.

Chicago/Turabian Style

Wu, Ruei-Er; Huang, Wen-Ching; Liao, Chen-Chung; Chang, Yu-Kai; Kan, Nai-Wen; Huang, Chi-Chang. 2013. "Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice." Molecules 18, no. 4: 4689-4702.



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