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Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice
Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan
Graduate Institute of Athletics and Coaching Science, College of Sports and Athletics, National Taiwan Sport University, Taoyuan 33301, Taiwan
Proteomics Research Center, National Yang-Ming University, Taipei 11221, Taiwan
Center for Liberal Arts, Taipei Medical University, Taipei 11031, Taiwan
* Authors to whom correspondence should be addressed.
Received: 4 February 2013; in revised form: 17 April 2013 / Accepted: 18 April 2013 / Published: 19 April 2013
Abstract: Resveratrol (RES) is a well-known phytocompound and food component which has antioxidative and multifunctional bioactivities. However, there is limited evidence for the effects of RES on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of trans-RES on fatigue and ergogenic functions following physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered RES for 21 days at 0, 25, 50, and 125 mg/kg/day, which were respectively designated the vehicle, RES-25, RES-50, and RES-125 groups. The anti-fatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. The exhaustive swimming time of the RES-25 group (24.72 ± 7.35 min) was significantly (p = 0.0179) longer than that of vehicle group (10.83 ± 1.15 min). A trend analysis revealed that RES treatments increased the grip strength. RES supplementation also produced dose-dependent decreases in serum lactate and ammonia levels and CK activity and also an increase in glucose levels in dose-dependent manners after the 15-min swimming test. The mechanism was related to the increased energy utilization (as blood glucose), and decreased serum levels of lactate, ammonia, and CK. Therefore, RES could be a potential agent with an anti-fatigue pharmacological effect.
Keywords: resveratrol; anti-fatigue; exercise performance; forelimb grip strength; ammonia; creatine kinase
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MDPI and ACS Style
Wu, R.-E.; Huang, W.-C.; Liao, C.-C.; Chang, Y.-K.; Kan, N.-W.; Huang, C.-C. Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice. Molecules 2013, 18, 4689-4702.
Wu R-E, Huang W-C, Liao C-C, Chang Y-K, Kan N-W, Huang C-C. Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice. Molecules. 2013; 18(4):4689-4702.
Wu, Ruei-Er; Huang, Wen-Ching; Liao, Chen-Chung; Chang, Yu-Kai; Kan, Nai-Wen; Huang, Chi-Chang. 2013. "Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice." Molecules 18, no. 4: 4689-4702.