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Molecules 2013, 18(4), 4679-4688; doi:10.3390/molecules18044679

Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity

1
Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400012, Victor Babes 41, Cluj-Napoca, Romania
2
Faculty of Chemistry and Chemical Engineering, "Babes Bolyai" University RO-400028, Arany Janos 11, Cluj-Napoca, Romania
3
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany
*
Authors to whom correspondence should be addressed.
Received: 11 March 2013 / Revised: 12 April 2013 / Accepted: 17 April 2013 / Published: 19 April 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG). View Full-Text
Keywords: selenazole; microwave assisted synthesis; cytotoxicity selenazole; microwave assisted synthesis; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Grozav Ignat, A.; Gaina, L.; Kuete, V.; Silaghi-Dumitrescu, L.; Efferth, T.; Zaharia, V. Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity. Molecules 2013, 18, 4679-4688.

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