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Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400012, Victor Babes 41, Cluj-Napoca, Romania
Faculty of Chemistry and Chemical Engineering, "Babes Bolyai" University RO-400028, Arany Janos 11, Cluj-Napoca, Romania
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany
* Authors to whom correspondence should be addressed.
Received: 11 March 2013; in revised form: 12 April 2013 / Accepted: 17 April 2013 / Published: 19 April 2013
Abstract: New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
Keywords: selenazole; microwave assisted synthesis; cytotoxicity
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Grozav Ignat, A.; Gaina, L.; Kuete, V.; Silaghi-Dumitrescu, L.; Efferth, T.; Zaharia, V. Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity. Molecules 2013, 18, 4679-4688.
Grozav Ignat A, Gaina L, Kuete V, Silaghi-Dumitrescu L, Efferth T, Zaharia V. Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity. Molecules. 2013; 18(4):4679-4688.
Grozav Ignat, Adriana; Gaina, Luiza; Kuete, Victor; Silaghi-Dumitrescu, Luminita; Efferth, Thomas; Zaharia, Valentin. 2013. "Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity." Molecules 18, no. 4: 4679-4688.