Molecules 2013, 18(4), 4389-4402; doi:10.3390/molecules18044389
Article

Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex

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Received: 8 February 2013; in revised form: 1 April 2013 / Accepted: 9 April 2013 / Published: 15 April 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture—protoescigenin—was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di-O,O-isopropylidene derivative in a validated large scale laboratory process.
Keywords: escin; protoescigenin hydrates; protoescigenin diacetonide; polymorphism; X-ray crystallography
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MDPI and ACS Style

Gruza, M.M.; Jatczak, K.; Zagrodzki, B.; Łaszcz, M.; Koziak, K.; Malińska, M.; Cmoch, P.; Giller, T.; Zegrocka-Stendel, O.; Woźniak, K.; Grynkiewicz, G. Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex. Molecules 2013, 18, 4389-4402.

AMA Style

Gruza MM, Jatczak K, Zagrodzki B, Łaszcz M, Koziak K, Malińska M, Cmoch P, Giller T, Zegrocka-Stendel O, Woźniak K, Grynkiewicz G. Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex. Molecules. 2013; 18(4):4389-4402.

Chicago/Turabian Style

Gruza, Mariusz M.; Jatczak, Kamil; Zagrodzki, Bogdan; Łaszcz, Marta; Koziak, Katarzyna; Malińska, Maura; Cmoch, Piotr; Giller, Tomasz; Zegrocka-Stendel, Oliwia; Woźniak, Krzysztof; Grynkiewicz, Grzegorz. 2013. "Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex." Molecules 18, no. 4: 4389-4402.


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