Molecules 2013, 18(4), 4389-4402; doi:10.3390/molecules18044389
Article

Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex

1 Pharmaceutical Research Institute, Rydygiera 8, Warszawa 01-793, Poland 2 Department of General and Nutritional Biochemistry, Warsaw Medical University, Żwirki i Wigury 61, Warszawa 02-091, Poland 3 Department of Chemistry, Warsaw University, Pasteura 1, Warszawa 02-093, Poland 4 Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44/52, Warszawa 01-224, Poland
* Author to whom correspondence should be addressed.
Received: 8 February 2013; in revised form: 1 April 2013 / Accepted: 9 April 2013 / Published: 15 April 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
PDF Full-text Download PDF Full-Text [984 KB, Updated Version, uploaded 16 April 2013 16:21 CEST]
The original version is still available [652 KB, uploaded 15 April 2013 09:30 CEST]
Abstract: A two-step chemical process for controlled degradation of escin, affording a mixture of olean-12-ene sapogenins, was elaborated and scaled up. The main component of the mixture—protoescigenin—was isolated and purified, in the form of its corresponding monohydrate, without resource to chromatographic methods. This material was further converted into the high purity 3,24;16,22-di-O,O-isopropylidene derivative in a validated large scale laboratory process.
Keywords: escin; protoescigenin hydrates; protoescigenin diacetonide; polymorphism; X-ray crystallography

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Gruza, M.M.; Jatczak, K.; Zagrodzki, B.; Łaszcz, M.; Koziak, K.; Malińska, M.; Cmoch, P.; Giller, T.; Zegrocka-Stendel, O.; Woźniak, K.; Grynkiewicz, G. Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex. Molecules 2013, 18, 4389-4402.

AMA Style

Gruza MM, Jatczak K, Zagrodzki B, Łaszcz M, Koziak K, Malińska M, Cmoch P, Giller T, Zegrocka-Stendel O, Woźniak K, Grynkiewicz G. Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex. Molecules. 2013; 18(4):4389-4402.

Chicago/Turabian Style

Gruza, Mariusz M.; Jatczak, Kamil; Zagrodzki, Bogdan; Łaszcz, Marta; Koziak, Katarzyna; Malińska, Maura; Cmoch, Piotr; Giller, Tomasz; Zegrocka-Stendel, Oliwia; Woźniak, Krzysztof; Grynkiewicz, Grzegorz. 2013. "Preparation, Purification and Regioselective Functionalization of Protoescigenin—The Main Aglycone of Escin Complex." Molecules 18, no. 4: 4389-4402.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert