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Molecules 2013, 18(3), 3427-3441; doi:10.3390/molecules18033427
Article

Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies

1,2,* , 1, 1, 1, 1,3 and 4,5,*
Received: 20 January 2013; in revised form: 8 March 2013 / Accepted: 11 March 2013 / Published: 14 March 2013
Download PDF [325 KB, uploaded 18 June 2014]
Abstract: We describe a new method of combinatorial screening in which building blocks, instead of being linked together chemically, are placed on the surface of nanoparticles. Two- or three-dimensional structures form on the surface of these particles through the close approach of different building blocks, with sufficient flexibility to be able to adapt and interact with putative binding sites in biological systems. The particles assemble without the need for formation of chemical bonds, so libraries comprised of many structures can be prepared rapidly, with large quantities of material available for testing. Screening methods can include solid and solution-phase binding assays, or tissue culture models, for example looking for structures which can change the behaviour of cells in a disease-modifying manner.
Keywords: mixed micelles; combinatorial biology; drug discovery; lipoamino acids; supramolecular aggregates; amphiphilic constructs; lipopetides mixed micelles; combinatorial biology; drug discovery; lipoamino acids; supramolecular aggregates; amphiphilic constructs; lipopetides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

New, R.; Bansal, G.S.; Bogus, M.; Zajkowska, K.; Rickelt, S.; Toth, I. Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies. Molecules 2013, 18, 3427-3441.

AMA Style

New R, Bansal GS, Bogus M, Zajkowska K, Rickelt S, Toth I. Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies. Molecules. 2013; 18(3):3427-3441.

Chicago/Turabian Style

New, Roger; Bansal, Gurpal S.; Bogus, Michael; Zajkowska, Kasia; Rickelt, Steffen; Toth, Istvan. 2013. "Use of Mixed Micelles for Presentation of Building Blocks in a New Combinatorial Discovery Methodology: Proof-of-Concept Studies." Molecules 18, no. 3: 3427-3441.


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