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Molecules 2013, 18(3), 3072-3085; doi:10.3390/molecules18033072
Article

Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta

1
,
2
,
1
,
2
 and
1,*
1 Drug Development Program, Biomedical Science Institute, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue 373, 21941-902, Rio de Janeiro, RJ, Brazil 2 Natural Products Research Nucleus, Health Science Center, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue 373, 21941-902, Rio de Janeiro, RJ, Brazil
* Author to whom correspondence should be addressed.
Received: 2 January 2013 / Revised: 27 February 2013 / Accepted: 1 March 2013 / Published: 7 March 2013
(This article belongs to the Section Metabolites)
Download PDF [234 KB, 18 June 2014; original version 18 June 2014]

Abstract

The essential oil of Pectis brevipedunculata (EOPB), a Brazilian ornamental aromatic grass, is characterized by its high content of citral (81.9%: neral 32.7% and geranial 49.2%), limonene (4.7%) and α-pinene (3.4%). Vasodilation induced by EOPB and isolated citral was investigated in pre-contracted vascular smooth muscle, using thoracic aorta from Wistar Kyoto (WKY) rats which was prepared for isometric tension recording. EOPB promoted intense relaxation of endothelium-intact and denuded aortic rings with the concentration to induce 50% of the maximal relaxation (IC50) of 0.044% ± 0.006% and 0.093% ± 0.015% (p < 0.05), respectively. The IC50 values for citral in endothelium-intact and denuded rings were 0.024% ± 0.004% and 0.021% ± 0.004%, respectively (p > 0.05). In endothelium-intact aorta, EOPB-induced vasorelaxation was significantly reduced by L-NAME, a nitric oxide synthase inhibitor. The vasodilator activity of citral was increased in the KCl-contracted aorta and citral attenuated the contracture elicited by Ca2+ in depolarized aorta. EOPB and citral elicited vasorelaxation on thoracic aorta by affecting the NO/cyclic GMP pathway and the calcium influx through voltage-dependent L-type Ca2+ channels, respectively.
Keywords: Pectis brevipedunculata; citral; vasodilator effect; L-type Ca2+ channel; NO/cyclic GMP pathway Pectis brevipedunculata; citral; vasodilator effect; L-type Ca2+ channel; NO/cyclic GMP pathway
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pereira, S.; Marques, A.; Sudo, R.T.; Kaplan, M.A.; Zapata-Sudo, G. Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta. Molecules 2013, 18, 3072-3085.

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