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Molecules 2013, 18(3), 2769-2777; doi:10.3390/molecules18032769
Article

Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone

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Received: 7 December 2012 / Revised: 31 January 2013 / Accepted: 7 February 2013 / Published: 1 March 2013
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Abstract

The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A (3), 173-ethoxypheophorbide A (4), 132-hydroxy phaeophytin B (5), 173-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by 1H- and 13C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.
Keywords: phytochemical study; Sida rhombifolia L.; Malvaceae; cryptolepinone; vasorelaxant activity phytochemical study; Sida rhombifolia L.; Malvaceae; cryptolepinone; vasorelaxant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chaves, O.S.; Gomes, R.A.; Tomaz, A.C.A.; Fernandes, M.G.; das Graças Mendes Junior, L.; de Fátima Agra, M.; Braga, V.A.; de Fátima Vanderlei de Souza, M. Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone. Molecules 2013, 18, 2769-2777.

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