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Molecules 2013, 18(3), 2769-2777; doi:10.3390/molecules18032769

Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone

Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, 58051-970, João Pessoa, PB, Brazil
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Received: 7 December 2012 / Revised: 31 January 2013 / Accepted: 7 February 2013 / Published: 1 March 2013
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Abstract

The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A (3), 173-ethoxypheophorbide A (4), 132-hydroxy phaeophytin B (5), 173-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by 1H- and 13C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time.
Keywords: phytochemical study; Sida rhombifolia L.; Malvaceae; cryptolepinone; vasorelaxant activity phytochemical study; Sida rhombifolia L.; Malvaceae; cryptolepinone; vasorelaxant activity
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MDPI and ACS Style

Chaves, O.S.; Gomes, R.A.; Tomaz, A.C.A.; Fernandes, M.G.; das Graças Mendes Junior, L.; de Fátima Agra, M.; Braga, V.A.; de Fátima Vanderlei de Souza, M. Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone. Molecules 2013, 18, 2769-2777.

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