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Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (No. BZ0150), Institute of Material Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
* Authors to whom correspondence should be addressed.
Received: 14 January 2013; in revised form: 18 January 2013 / Accepted: 18 January 2013 / Published: 25 January 2013
Abstract: Two new aromatic compounds, butyl 2,5-dihydroxyphenylacetate (1) and butyl 2-O-β-D-glucopyranosyloxy-5-dihydroxyphenylacetate (2), together with three known ones, methyl 2,5-dihydroxyphenylacetate (3), ethyl 2,5-dihydroxyphenylacetate (4) and 2-O-β-D-glucopyranosyloxy-5-hydroxyphenylacetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC50 values of 9.80 μM, 11.70 μM and 9.93 μM, respectively.
Keywords: Entada phaseoloides; Leguminosae; 2,5-dihydroxyphenylacetic acid; HIV-1
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MDPI and ACS Style
Chen, L.; Zhang, Y.; Ding, G.; Ba, M.; Guo, Y.; Zou, Z. Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides. Molecules 2013, 18, 1477-1482.
Chen L, Zhang Y, Ding G, Ba M, Guo Y, Zou Z. Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides. Molecules. 2013; 18(2):1477-1482.
Chen, Lin; Zhang, Yong; Ding, Gang; Ba, Mingyu; Guo, Ying; Zou, Zhongmei. 2013. "Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides." Molecules 18, no. 2: 1477-1482.