Molecules 2013, 18(2), 1477-1482; doi:10.3390/molecules18021477
Article

Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides

1email, 1email, 1email, 2email, 2,* email and 1,* email
Received: 14 January 2013; in revised form: 18 January 2013 / Accepted: 18 January 2013 / Published: 25 January 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Two new aromatic compounds, butyl 2,5-dihydroxyphenylacetate (1) and butyl 2-O-β-D-glucopyranosyloxy-5-dihydroxyphenylacetate (2), together with three known ones, methyl 2,5-dihydroxyphenylacetate (3), ethyl 2,5-dihydroxyphenylacetate (4) and 2-O-β-D-glucopyranosyloxy-5-hydroxyphenylacetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC50 values of 9.80 μM, 11.70 μM and 9.93 μM, respectively.
Keywords: Entada phaseoloides; Leguminosae; 2,5-dihydroxyphenylacetic acid; HIV-1
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MDPI and ACS Style

Chen, L.; Zhang, Y.; Ding, G.; Ba, M.; Guo, Y.; Zou, Z. Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides. Molecules 2013, 18, 1477-1482.

AMA Style

Chen L, Zhang Y, Ding G, Ba M, Guo Y, Zou Z. Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides. Molecules. 2013; 18(2):1477-1482.

Chicago/Turabian Style

Chen, Lin; Zhang, Yong; Ding, Gang; Ba, Mingyu; Guo, Ying; Zou, Zhongmei. 2013. "Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides." Molecules 18, no. 2: 1477-1482.

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