Synthesis of Thiophene and NO-Curcuminoids for Antiinflammatory and Anti-Cancer Activities
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Pharmacology
2.2.1. Cytotoxicity
2.2.2. Nitric Oxide Production
2.2.3. Cytokine Production
2.2.4. Chemokine Production
2.2.5. Discussion of Pharmacology and Conclusions
3. Experimental
3.1. Chemistry: General
3.1.1. Preparation of tri-sec-Butyl Borate
3.1.2. General Procedure for the Synthesis of Bromobutoxybenzaldehydes 6a–d
3.1.3. Synthesis of Curcuminoids
3.1.4. Synthesis of Nitroxybutyl Curcuminoids 9a–d
3.2. Pharmacology
3.2.1. General Procedures for Cell Cultures And Compound Preparations
3.2.2. Nitric Oxide Assay
3.2.3. Sandwich ELISA Assay
Acknowledgments
References
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Sample Availability: Samples of the compounds 9a–d, 10a–c and 11 are available from the authors. |
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Ahmed, M.M.; Khan, M.A.; Rainsford, K.D. Synthesis of Thiophene and NO-Curcuminoids for Antiinflammatory and Anti-Cancer Activities. Molecules 2013, 18, 1483-1501. https://doi.org/10.3390/molecules18021483
Ahmed MM, Khan MA, Rainsford KD. Synthesis of Thiophene and NO-Curcuminoids for Antiinflammatory and Anti-Cancer Activities. Molecules. 2013; 18(2):1483-1501. https://doi.org/10.3390/molecules18021483
Chicago/Turabian StyleAhmed, Mahera M., M. Akram Khan, and Kim Drummond Rainsford. 2013. "Synthesis of Thiophene and NO-Curcuminoids for Antiinflammatory and Anti-Cancer Activities" Molecules 18, no. 2: 1483-1501. https://doi.org/10.3390/molecules18021483