Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine

doi:10.3390/molecules18021464

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Molecules 2013, 18(2), 1464-1476; doi:10.3390/molecules18021464

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Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine

Ivana M. Marzano¹, Marina S. Franco¹, Priscila P. Silva¹, Rodinei Augusti¹, Geandson C. Santos¹, Nelson G. Fernandes¹, Mônica Bucciarelli-Rodriguez², Edmar Chartone-Souza² and Elene C. Pereira-Maia^1,*

¹ Department of Chemistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil ² Department of General Biology, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil

* Author to whom correspondence should be addressed.

Received: 21 December 2012; in revised form: 17 January 2013 / Accepted: 17 January 2013 / Published: 24 January 2013

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Abstract: A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl₃(C₁₁H₁₁N₃O₂S)₃]. The structure of the complex reveals a distorted octahedral geometry around the bismuth atom, which is bound to three sulfonamidic nitrogens from sulfapyridine, acting as a monodentate ligand, and to three chloride ions. The presence of the compound in solution was confirmed by ESI-MS studies. The complex is 3 times more potent than the ligand against Salmonella typhimurium, 4 times against Staphylococcus aureus, Shigella dysenteriae, and Shigella sonnei and 8 times more potent against Pseudomonas aeruginosa and Escherichia coli. The compound inhibits the growth of chronic myelogenous leukemia cells with an IC₅₀ value of 44 μM whereas the free ligand has no effect up to 100 μM.

Keywords: Bi(III) complex; sulfapyridine; X-ray structure; antimicrobial activity; cytotoxic activity

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Cite This Article

MDPI and ACS Style

Marzano, I.M.; Franco, M.S.; Silva, P.P.; Augusti, R.; Santos, G.C.; Fernandes, N.G.; Bucciarelli-Rodriguez, M.; Chartone-Souza, E.; Pereira-Maia, E.C. Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine. Molecules 2013, 18, 1464-1476.

AMA Style

Marzano IM, Franco MS, Silva PP, Augusti R, Santos GC, Fernandes NG, Bucciarelli-Rodriguez M, Chartone-Souza E, Pereira-Maia EC. Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine. Molecules. 2013; 18(2):1464-1476.

Chicago/Turabian Style

Marzano, Ivana M.; Franco, Marina S.; Silva, Priscila P.; Augusti, Rodinei; Santos, Geandson C.; Fernandes, Nelson G.; Bucciarelli-Rodriguez, Mônica; Chartone-Souza, Edmar; Pereira-Maia, Elene C. 2013. "Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine." Molecules 18, no. 2: 1464-1476.

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