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Molecules 2013, 18(2), 1464-1476; doi:10.3390/molecules18021464
Article

Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine

1, 1, 1, 1, 1, 1, 2, 2 and 1,*
1 Department of Chemistry, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil 2 Department of General Biology, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte 31270-901, MG, Brazil
* Author to whom correspondence should be addressed.
Received: 21 December 2012 / Revised: 17 January 2013 / Accepted: 17 January 2013 / Published: 24 January 2013
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Abstract

A new complex of Bi(III) and sulfapyridine was synthesized and characterized by elemental analysis, atomic absorption spectrometry, conductivity analysis, electrospray ionization mass spectrometry (ESI-MS), infrared spectroscopy, and single crystal X-ray diffraction methods. The antimicrobial and the cytotoxic activities of the compound were investigated. Elemental and conductivity analyses are in accordance to the formulation [BiCl3(C11H11N3O2S)3]. The structure of the complex reveals a distorted octahedral geometry around the bismuth atom, which is bound to three sulfonamidic nitrogens from sulfapyridine, acting as a monodentate ligand, and to three chloride ions. The presence of the compound in solution was confirmed by ESI-MS studies. The complex is 3 times more potent than the ligand against Salmonella typhimurium, 4 times against Staphylococcus aureus, Shigella dysenteriae, and Shigella sonnei and 8 times more potent against Pseudomonas aeruginosa and Escherichia coli. The compound inhibits the growth of chronic myelogenous leukemia cells with an IC50 value of 44 μM whereas the free ligand has no effect up to 100 μM.
Keywords: Bi(III) complex; sulfapyridine; X-ray structure; antimicrobial activity; cytotoxic activity Bi(III) complex; sulfapyridine; X-ray structure; antimicrobial activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marzano, I.M.; Franco, M.S.; Silva, P.P.; Augusti, R.; Santos, G.C.; Fernandes, N.G.; Bucciarelli-Rodriguez, M.; Chartone-Souza, E.; Pereira-Maia, E.C. Crystal Structure, Antibacterial and Cytotoxic Activities of a New Complex of Bismuth(III) with Sulfapyridine. Molecules 2013, 18, 1464-1476.

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