Degradation Kinetics of Atorvastatin under Stress Conditions and Chemical Analysis by HPLC
Abstract
:1. Introduction
2. Results and Discussion
2.1. Validation of Analytical Method and Research of Degradation Products
2.2. The Degradation Kinetics under Acid and Basic Conditions
3. Experimental
3.1. Development, Optimization, and Validation of Analytical Method
3.2. Search for Degradation Products after Exposure to Stress Conditions
3.3. Evaluation of Degradation Kinetics under Acid and Basic Conditions
4. Conclusions
Acknowledgments
References
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Sample Availability: Samples of the atorvastatin are available from the authors. |
Conditions | Retention time (tR) (min) | Área (au) | Concentration (mg/mL) |
---|---|---|---|
Atorvastatin | 3.843 | 789,324.00 | 4 × 10−2 |
After 30 min | 3.824 | 64,904.00 | 3.289093 × 10−3 |
After 60 min | 3.824 | 59,718.00 | 3.026286 × 10−3 |
After 90 min | 3.824 | 24,468.00 | 1.239947 × 10−3 |
After 120 min | 3.829 | 13,311.00 | 6.74552 × 10−4 |
Parameters | Orders | ||
---|---|---|---|
Zero (C × time) | First (log C × time) | Second (1/log C × time) | |
r (linear correlation coefficient) | 0.959518923 | 0.961904152 | 0.93865055 |
k (rate constant) | 3.20999 × 10−5 | 1.8820799 × 10−2 | 13.37113094 |
Conditions | Retention time (tR) (min) | Área (au) | Concentration (mg/mL) |
---|---|---|---|
Atorvastatin | 3.843 | 789,324.00 | 4 × 10−2 |
After 30 min | 3.835 | 586,493.00 | 2.972128 × 10−2 |
After 60 min | 3.832 | 446,381.00 | 2.2620926 × 10−2 |
After 90 min | 3.827 | 340,651.00 | 1.7262923 × 10−2 |
After 120 min | 3.830 | 157,439.00 | 7.978422 × 10−3 |
Parameters | Orders | ||
---|---|---|---|
Zero (C × time) | First (log C × time) | Second (1/log C × time) | |
r (linear correlation coefficient) | 0.99448374 | 0.96033586 | 0.903743452 |
k (rate constant) | 2.35289 × 10−4 | 1.4054805 × 10−2 | 0.962657291 |
© 2013 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
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Oliveira, M.A.; Yoshida, M.I.; Belinelo, V.J.; Valotto, R.S. Degradation Kinetics of Atorvastatin under Stress Conditions and Chemical Analysis by HPLC. Molecules 2013, 18, 1447-1456. https://doi.org/10.3390/molecules18021447
Oliveira MA, Yoshida MI, Belinelo VJ, Valotto RS. Degradation Kinetics of Atorvastatin under Stress Conditions and Chemical Analysis by HPLC. Molecules. 2013; 18(2):1447-1456. https://doi.org/10.3390/molecules18021447
Chicago/Turabian StyleOliveira, Marcelo Antonio, Maria Irene Yoshida, Valdenir José Belinelo, and Romanélia Spessemille Valotto. 2013. "Degradation Kinetics of Atorvastatin under Stress Conditions and Chemical Analysis by HPLC" Molecules 18, no. 2: 1447-1456. https://doi.org/10.3390/molecules18021447