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Retraction published on 9 September 2013, see Molecules 2013, 18(9), 11001-11002.

Open AccessArticle
Molecules 2013, 18(2), 1434-1446; doi:10.3390/molecules18021434

Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines

1
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
2
Chemistry of Natural products Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt
3
Cancer Biology Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt
4
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
5
Textile Research Division, National Research Center, Dokki 12622, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 24 December 2012 / Revised: 10 January 2013 / Accepted: 14 January 2013 / Published: 24 January 2013
(This article belongs to the Section Medicinal Chemistry)
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Abstract

A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 125 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 68 and 25 are promising multi-potent anti-inflammatory agents.
Keywords: 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Al-Salahi, R.A.; Gamal-Eldeen, A.M.; Alanazi, A.M.; Al-Omar, M.A.; Marzouk, M.A.; Fouda, M.M.G. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules 2013, 18, 1434-1446.

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