Next Article in Journal
Degradation Kinetics of Atorvastatin under Stress Conditions and Chemical Analysis by HPLC
Previous Article in Journal
Induction of Apoptosis by Costunolide in Bladder Cancer Cells is Mediated through ROS Generation and Mitochondrial Dysfunction
This paper was retracted on 9 September 2013, see Molecules 2013, 18(9), 11001-11002.

Molecules 2013, 18(2), 1434-1446; doi:10.3390/molecules18021434

Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines

1,* , 2, 1, 1, 1,3 and 4,5
Received: 24 December 2012 / Revised: 10 January 2013 / Accepted: 14 January 2013 / Published: 24 January 2013
Download PDF [239 KB, uploaded 18 June 2014]


A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 125 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 68 and 25 are promising multi-potent anti-inflammatory agents.
Keywords: 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Al-Salahi, R.A.; Gamal-Eldeen, A.M.; Alanazi, A.M.; Al-Omar, M.A.; Marzouk, M.A.; Fouda, M.M.G. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules 2013, 18, 1434-1446.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert