Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
AbstractA series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6–8 and 25 are promising multi-potent anti-inflammatory agents.
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Al-Salahi, R.A.; Gamal-Eldeen, A.M.; Alanazi, A.M.; Al-Omar, M.A.; Marzouk, M.A.; Fouda, M.M.G. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules 2013, 18, 1434-1446.
Al-Salahi RA, Gamal-Eldeen AM, Alanazi AM, Al-Omar MA, Marzouk MA, Fouda MMG. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules. 2013; 18(2):1434-1446.Chicago/Turabian Style
Al-Salahi, Rashad A.; Gamal-Eldeen, Amira M.; Alanazi, Amer M.; Al-Omar, Mohamed A.; Marzouk, Mohamed A.; Fouda, Moustafa M.G. 2013. "Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines." Molecules 18, no. 2: 1434-1446.