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Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
Chemistry of Natural products Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt
Cancer Biology Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Textile Research Division, National Research Center, Dokki 12622, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 24 December 2012; in revised form: 10 January 2013 / Accepted: 14 January 2013 / Published: 24 January 2013
Abstract: A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 1–25 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 6–8 and 25 are promising multi-potent anti-inflammatory agents.
Keywords: 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation
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MDPI and ACS Style
Al-Salahi, R.A.; Gamal-Eldeen, A.M.; Alanazi, A.M.; Al-Omar, M.A.; Marzouk, M.A.; Fouda, M.M.G. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules 2013, 18, 1434-1446.
Al-Salahi RA, Gamal-Eldeen AM, Alanazi AM, Al-Omar MA, Marzouk MA, Fouda MMG. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules. 2013; 18(2):1434-1446.
Al-Salahi, Rashad A.; Gamal-Eldeen, Amira M.; Alanazi, Amer M.; Al-Omar, Mohamed A.; Marzouk, Mohamed A.; Fouda, Moustafa M.G. 2013. "Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines." Molecules 18, no. 2: 1434-1446.