This paper was retracted on 9 September 2013, see Molecules 2013, 18(9), 11001-11002.

Molecules 2013, 18(2), 1434-1446; doi:10.3390/molecules18021434
Article

Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines

1,* email, 2, 1, 1, 1,3 and 4,5
Received: 24 December 2012; in revised form: 10 January 2013 / Accepted: 14 January 2013 / Published: 24 January 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 125 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 68 and 25 are promising multi-potent anti-inflammatory agents.
Keywords: 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation
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MDPI and ACS Style

Al-Salahi, R.A.; Gamal-Eldeen, A.M.; Alanazi, A.M.; Al-Omar, M.A.; Marzouk, M.A.; Fouda, M.M.G. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules 2013, 18, 1434-1446.

AMA Style

Al-Salahi RA, Gamal-Eldeen AM, Alanazi AM, Al-Omar MA, Marzouk MA, Fouda MMG. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules. 2013; 18(2):1434-1446.

Chicago/Turabian Style

Al-Salahi, Rashad A.; Gamal-Eldeen, Amira M.; Alanazi, Amer M.; Al-Omar, Mohamed A.; Marzouk, Mohamed A.; Fouda, Moustafa M.G. 2013. "Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines." Molecules 18, no. 2: 1434-1446.


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