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This paper was retracted on 9 September 2013, see Molecules 2013, 18(9), 11001-11002.

Molecules 2013, 18(2), 1434-1446; doi:10.3390/molecules18021434
Article

Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines

1,* , 2, 1, 1, 1,3 and 4,5
1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia 2 Chemistry of Natural products Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt 3 Cancer Biology Group, Center of Excellence for Advanced Sciences, National Research Center, Dokki 12622, Cairo, Egypt 4 Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 5 Textile Research Division, National Research Center, Dokki 12622, Cairo, Egypt
* Author to whom correspondence should be addressed.
Received: 24 December 2012 / Revised: 10 January 2013 / Accepted: 14 January 2013 / Published: 24 January 2013
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Abstract

A series of twenty five 2-methylsulfanyl-[1,2,4]triazolo[1,5-a]quinazoline derivatives 125 was previously synthesized. We have now investigated their cytotoxic effects against hepatocellular Hep-G2 and colon HCT-116 carcinoma cells and effect on the macrophage growth, in addition to their influence of the inflammatory mediators [nitric oxide (NO), tumor necrosis factor-α (TNF-α), prostaglandin E-2 (PGE-2) and in bacterial lipopolysachharide (LPS)-stimulated macrophages]. The findings revealed that compounds 13 and 17 showed the highest cytotoxicity and that 3, 68 and 25 are promising multi-potent anti-inflammatory agents.
Keywords: 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation 1,2,4-triazoloquinazoline; antitumor; Hep-G2; HCT-116; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Al-Salahi, R.A.; Gamal-Eldeen, A.M.; Alanazi, A.M.; Al-Omar, M.A.; Marzouk, M.A.; Fouda, M.M.G. Cytotoxicity and Anti-Inflammatory Activity of Methylsulfanyl-triazoloquinazolines. Molecules 2013, 18, 1434-1446.

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