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Molecules 2013, 18(2), 1405-1417; doi:10.3390/molecules18021405
Article

Cytotoxic and Radical Scavenging Nor-Dammarane Triterpenoids from Viburnum mongolicum

1 and 2,*
1 Department of Pharmacy, No.202 Hospital of PLA, Shenyang 110003, China 2 Department of Pharmacy, No.455 Hospital of PLA, Shanghai 200052, China
* Author to whom correspondence should be addressed.
Received: 11 December 2012 / Revised: 28 December 2012 / Accepted: 5 January 2013 / Published: 24 January 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Abstract

The ethanol extract of the whole plants of Viburnum mongolicum afforded six new nor-dammarane triterpenoids: 3β,12β-dihydroxy-25,26,27-trinordammara-22-en -24,20-olide (1), 3β,12β-dihydroxy-24α-methoxy-25,26,27-trinordammara-20,24-epoxy (2), 3β-O-acetyl-12β-hydroxy-23,24,25,26,27-hexanordammarane-20-one (3), 12β-O- acetyl-15α-hydroxy-17β-methoxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanrane (4), 12β-O-acetyl-15α,17β-dihydroxy-3-oxo-20,21,22-23,24,25,26,27-octanordammanrane (5), and 12β,15α-dihydroxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanrane (6), together with two known nor-dammarane triterpenoids, 12β-hydroxy-3-oxo-24α-methoxy- 25,26,27-trinordammara-20,24-epoxy (7) and 3β,12β-dihydroxy-23,24,25,26,27- hexanordammarane-20-one (8). The structures of the isolated compounds were established based on 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic potential against seven tumor cell lines and radical scavenging activities. Compounds 46 exhibited significant cytotoxic activities against all tested tumor cell lines and radical scavenging activities against ABTS·+ radicals comparable with the standard drug Trolox.
Keywords: Viburnum mongolicum; Caprifliaceae; nor-dammarane triterpenoids; cytotoxicity; radical scavenging activities Viburnum mongolicum; Caprifliaceae; nor-dammarane triterpenoids; cytotoxicity; radical scavenging activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, X.; Wang, W. Cytotoxic and Radical Scavenging Nor-Dammarane Triterpenoids from Viburnum mongolicum. Molecules 2013, 18, 1405-1417.

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