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A New Triterpenoid from Teucrium viscidum
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Central Research Institute, Shanghai Pharmaceutical Holding Co. Ltd, 898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 3 December 2012; in revised form: 1 January 2013 / Accepted: 7 January 2013 / Published: 21 January 2013
Abstract: A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 1–4 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).
Keywords: Teucrium viscidum; triterpenoids; lignans; 11β-HSD1
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MDPI and ACS Style
Hao, X.; Zhang, J.; Xia, G.; Xue, Y.; Luo, Z.; Si, Y.; Yao, G.; Zhang, Y. A New Triterpenoid from Teucrium viscidum. Molecules 2013, 18, 1262-1269.
Hao X, Zhang J, Xia G, Xue Y, Luo Z, Si Y, Yao G, Zhang Y. A New Triterpenoid from Teucrium viscidum. Molecules. 2013; 18(1):1262-1269.
Hao, Xincai; Zhang, Jinwen; Xia, Guangxin; Xue, Yongbo; Luo, Zengwei; Si, Yanyan; Yao, Guangmin; Zhang, Yonghui. 2013. "A New Triterpenoid from Teucrium viscidum." Molecules 18, no. 1: 1262-1269.