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Molecules 2013, 18(1), 1262-1269; doi:10.3390/molecules18011262
Article

A New Triterpenoid from Teucrium viscidum

1,†, 2,†, 3, 1, 1, 1, 1,*  and 1,*
1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2 Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 3 Central Research Institute, Shanghai Pharmaceutical Holding Co. Ltd, 898 Halei Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 3 December 2012 / Revised: 1 January 2013 / Accepted: 7 January 2013 / Published: 21 January 2013
(This article belongs to the Special Issue Triterpenes and Triterpenoids)
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Abstract

A new ursane-type triterpenoid, 3β-hydroxy-urs-30-p-Z-hydroxycinnamoyloxy-12-en-28-oic-acid (1), together with three known triterpenoids, 3β-hydroxy-urs-30-p-E-hydroxycinnamoyloxy-12-en-28-oic-acid (2), 2α,3β,19α-trihydroxy-urs-12-en-28-oic-acid (3), and ursolic acid (4), four known lignans, pinoresinol (5), 9α-hydroxypinoresinol (6), (+)-medioresinol (7), and (+)-kobusin (8), and two steroids, β-sitosterol (9), and daucosterol (10), were isolated from the whole parts of Teucrium viscidum. Their structures were established by a combination of spectroscopic data analysis, besides comparison with literature data. Compounds 14 were evaluated for their inhibitory activities against 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1).
Keywords: Teucrium viscidum; triterpenoids; lignans; 11β-HSD1 Teucrium viscidum; triterpenoids; lignans; 11β-HSD1
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hao, X.; Zhang, J.; Xia, G.; Xue, Y.; Luo, Z.; Si, Y.; Yao, G.; Zhang, Y. A New Triterpenoid from Teucrium viscidum. Molecules 2013, 18, 1262-1269.

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