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Molecules 2013, 18(2), 1368-1382; doi:10.3390/molecules18021368
Article

Profiling and Characterization of Volatile Components from Non-Fumigated and Sulfur-Fumigated Flos Lonicerae Japonicae Using Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Coupled with Chemical Group Separation

1,2,3,†,* , 2,3,4,†, 5,†, 1,2,3, 1,2, 6, 1,2, 1,2, 7 and 1,2,3,4,*
Received: 25 October 2012; in revised form: 10 January 2013 / Accepted: 14 January 2013 / Published: 24 January 2013
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Abstract: Flos Lonicerae Japonicae (FLJ) is a popular herb used for many centuries in Traditional Chinese Medicine as a treatment of fever and inflammation. Non-fumigated processing of FLJ has been the traditional approach used in post-harvest preparation of the commodity for commercial use. However, in recent years, natural drying processing of FLJ has been replaced by sulfur-fumigation for efficiency and pest control. Sulfur-fumigation can induce changes in the volatile compounds of the herb, altering its medicinal properties. A comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF/MS) method was established for the resolution and determination of volatile components in non-fumigated and sulfur-fumigated FLJ. In this paper, analysis of the volatile oils in non-fumigated and sulfur-fumigated (including lab-prepared sulfur- fumigated and industrial sulfur-fumigated) FLJ was performed using GC×GC-TOF/MS. Seventy-three representative volatile components were identified, including furans, alkalies, acids, aldehydes, ketones, alcohols, terpenes, esters, and others, as the main components of FLJ volatile oils. The proposed method was successfully applied for rapid and accurate quality evaluation of FLJ and its related medicinal materials and preparations.
Keywords: sulfur-fumigation; GC×GC-TOF/MS; volatile compounds; Flos Lonicerae Japonicae; quality control sulfur-fumigation; GC×GC-TOF/MS; volatile compounds; Flos Lonicerae Japonicae; quality control
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cai, H.; Cao, G.; Li, L.; Liu, X.; Ma, X.-Q.; Tu, S.-C.; Lou, Y.-J.; Qin, K.-M.; Li, S.-L.; Cai, B.-C. Profiling and Characterization of Volatile Components from Non-Fumigated and Sulfur-Fumigated Flos Lonicerae Japonicae Using Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Coupled with Chemical Group Separation. Molecules 2013, 18, 1368-1382.

AMA Style

Cai H, Cao G, Li L, Liu X, Ma X-Q, Tu S-C, Lou Y-J, Qin K-M, Li S-L, Cai B-C. Profiling and Characterization of Volatile Components from Non-Fumigated and Sulfur-Fumigated Flos Lonicerae Japonicae Using Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Coupled with Chemical Group Separation. Molecules. 2013; 18(2):1368-1382.

Chicago/Turabian Style

Cai, Hao; Cao, Gang; Li, Li; Liu, Xiao; Ma, Xiao-Qing; Tu, Si-Cong; Lou, Ya-Jing; Qin, Kun-Ming; Li, Song-Lin; Cai, Bao-Chang. 2013. "Profiling and Characterization of Volatile Components from Non-Fumigated and Sulfur-Fumigated Flos Lonicerae Japonicae Using Comprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometry Coupled with Chemical Group Separation." Molecules 18, no. 2: 1368-1382.



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